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Detection of CD44v6 in mesorectum from total mesorectal excision: an analysis of 47 cases
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 20
- DOI:
- 10.3969/j.issn.1009-3079.2005.20.027
- Key Word:
- CD44v6;直肠系膜;SP免疫组化
Abstract： 目的:通过检测CD44v6在的直肠癌及直肠系膜内的表达,从分子水平证明全直肠系膜切除术治疗直肠癌的科学性.方法:行全直肠系膜切除术的直肠癌患者47例于直肠癌组织、直肠系膜(距肿瘤下缘2 cm)、直肠系膜远端切缘(距肿瘤下缘5 cm)取病理标本,采用免疫组化SP法对标本进行CD44v6检测.结果:直肠癌组织中CD44v6高度表达,正常直肠系膜组织中CD44v6的阳性表达率(0/20)与直肠系膜(距肿瘤下缘2 cm)的CD44v6的阳性表达率(15/47)存在显著差异(P＜0.01),而与直肠系膜远端切缘(4/47)无差异(P＞0.05).同时发现直肠癌中CD44v6的阳性表达率与肿瘤的淋巴转移(有vs无:88.5%vs 61.9%,P＜0.05)和临床分期(Dukes C-D vs A-B:88.5% vs61.9%,P＜0.05)有关.结论:对直肠癌组织进行CD44v6蛋白的检测,有助于评估直肠系膜局部病变程度;肿瘤远端直肠系膜切除长度至少比肿瘤平面多5 cm.
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