You Position: Home > Paper
Application of bcl-2 gene in study of tumors of digestive tract
( views:139, downloads:1 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 10
- DOI:
- 10.3969/j.issn.1009-3079.2005.10.012
- Key Word:
- No keyword available
Abstract： bcl-2基因是被发现的第一个抑制细胞凋亡的基因,对各种原因引起的细胞凋亡具有抑制作用,可导致DNA受损的细胞持续生存,突变产物聚集.其表达可增加细胞对多种促凋亡因素的抵抗性,在细胞的程序化死亡中起着非常重要的作用.bcl-2基因编码的蛋白质主要分布于线粒体、核膜及内质网上,不影响细胞的增殖,可通过抵抗细胞凋亡,延长细胞的寿命,促进细胞生存,从而使肿瘤发生发展.近年来研究发现,bcl-2基因在食管癌、胃癌、肝癌、胰腺癌、大肠癌的发生发展中起重要作用.
- [1]郭琳琅,曹长安,郭颖.肝硬变和肝癌组织bcl-2及相关蛋白bax的表达及意义[J].1998,(3).
- [2]周晓东,姜阳,刘蕴蘅.胃癌组织bcl-2蛋白表达和DCC基因的杂合性缺失[J].1998,(3).
- [3]郭琳琅,肖莎.应用原位杂交技术检测原发性肝癌组织中bcl-2基因断裂点[J].1998,(4).
- [4]李胜,李占元,张卫东.人胰腺癌中bcl-2基因和蛋白的过度表达[J].2002,(3).
- [5]D, Ofner,K, Riehemann,H, Maier,etc.Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival.[J].1995,72.
- [6]AJM Wason,AJ Mrr,S Jons,etc.Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas[J].1996,73(8).
- [7]李雪莉,郝远瑞,邹建湘,等.C-MYC,BCL-2与胃癌生物学行为和细胞凋亡[J].1997,(12).
- [8]Elizabeth Yang,Jiping Zha,Jennifer Jockel,etc.Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death[J].1995,80(2).
- [9]Ebinuma H,Saito H,Miyashita T,etc.Overexpression of Bcl-2 protects human hepatoma cells from Fas-antibody-mediated apoptosis.[J].1999,31(2).
- [10]F A, Sinicrope,S B, Ruan,K R, Cleary,etc.Bcl-2 and P53 Oncoprotein Expression During Colorectal Tumorigenesis.[J].1995,55.
- [11]Yang JL,Berney CR,Downing SR,etc.Evidence for post-transcriptional down-regulation of the apoptosis-related gene bcl-2 in human colorectal cancer.[J].2000,191(1).