Paper - WANFANG MED ONLINE

You Position: Home > Paper

Progress in specific GGT for diagnosis of liver cancer

( views:121, downloads:25 )

Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 9

DOI:: 10.3969/j.issn.1009-3079.2005.09.017

Key Word:: No keyword available

Abstract： γ-谷氨酰转移酶(gamma-glutamyltransferase,GGT)及其同工酶作为肝癌的标记物日益受到重视,GGT-Ⅱ已成为AFP以外的最佳肝癌标志物,并在检测方法和临床应用等方面有了较多新的进展.本文就GGT基因的分子结构和基因构成、肝内分布特点及肝癌时的异常表达机制、检测及临床价值等作一综述.

Reference

[1]苗爱莲,李军,魏曙亚,等.肝癌特异γ-谷氨酰转肽酶同功酶Ⅱ活性检测及其临床价值[J].2003,(1).
[2]倪润洲,黄介飞,肖明兵,等.单抗免疫酶斑点法检测GGT-Ⅱ在肝癌诊断中的价值[J].2004,(1).
[3]汤伟,汪晓莺,高建恩,等.肝癌特异性谷氨酰转肽酶单克隆抗体的制备与初步应用[J].2003,(2).
[4]RW Parks,OJ Garden.Liver resection for cancer[J].2001,(6).
[5]Guo-Qing Han,Cheng-Yong Qin,Rong-hua SHU.The analysis of γ-glutamyl transpeptidase gene in different type liver tissues[J].2003,(2).
[6]秦成坤,彭志海,韩国庆.外周血γ-谷氨酰转移酶mRNA-H亚型与甲胎蛋白对原发性肝癌诊断及肝外转移意义的比较[J].2004,(6).
[7]于嘉屏,王爱华,顾鹏飞,等.免疫沉淀法测定血清中与两种脂蛋白结合的γ-谷氨酰基转移酶活性及其诊断肝癌的价值[J].2003,(6).
[8]黄介飞,姚登福,孟宪镛,等.肝癌特异性GGT火箭电泳对原发性肝癌的诊断价值[J].1995,(5).
[9]K, Xu,X Y, Meng,J W, Wu,etc.Diagnostic value of serum gamma-glutamyl transferase isoenzyme for hepatocellular carcinoma: a 10-year study.[J].1992,87.
[10]Teubner A,Habeck JO,Ernstberger J,etc.Isolated elevation of gGT: What should be the diagnostic approach?[J].2004,129(Suppl.2).
[11]司维柯,李士敏,罗朝学.伴刀豆球蛋白A识别正常与肝癌γ-谷氨酰转移酶的实验观察[J].2000,(3).
[12]沈鼎明,沈薇.血清肝癌标志物在原发性肝癌诊断中的价值：-附...[J].1992,012 (4).
[13]K C, Xu,X Y, Meng,Y C, Shi,etc.The diagnostic value of a hepatoma-specific band of serum gamma-glutamyl transferase.[J].1985,36.
[14]Mathisen O,Visvikis A,Bremnes R,etc.Heterogeneity in gamma-glutamyltransferase mRNA expression and glycan structures. Search for tumor-specific variants in human liver metastases and colon carcinoma cells.[J].2003,1648(1).
[15]Visvikis Athanase,Pawlak Andre,Accaoui Marie Jose,etc.Structure of the 5' sequences of the human gamma-glutamyltransferase gene[J].2001.
[16]M, Tsutsumi,D, Sakamuro,A, Takada,etc.Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma.[J].1996,23.
[17]Courtay C,Heisterkamp N,Siest G,etc.Expression of multiple\u03b3 -glutamyltransferase genes in man[J].1994.
[18]S N, Hochwald,L E, Harrison,D M, Rose,etc.gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo.[J].1996,88.
[19]K S, Jeng,I S, Sheen,Y C, Tsai.Gamma-glutamyl transpeptidase messenger RNA may serve as a diagnostic aid in hepatocellular carcinoma.[J].2001,88(7).
[20]Addolorato G,Rossi C,Pompili M,etc.Evaluation of the albumin-gamma-glutamyltransferase isoenzyme as a diagnostic marker of hepatocellular carcinoma-complicating liver cirrhosis.[J].2003,18(3).
[21]Hirata R,Tomita K,Fujiyama S,etc.Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma.[J].2002,62(Suppl.1).
[22]D F, Yao,Z W, Huang,S Z, Chen,etc.Diagnosis of hepatocellular carcinoma by quantitative detection of hepatoma-specific bands of serum gamma-glutamyltransferase.[J].1998,110.
[23]M, Ohata,G, Toda.[Gamma-glutamyltranspeptidase (gamma-GT)].[J].2001,Suppl 116.
[24]Katsuko Yamashita,Kazuhide Totani,Yo Iwaki,etc.Comparative Study of the Sugar Chains of γ-Glutamyltranspeptidases Purified from Human Hepatocellular Carcinoma and from Human Liver[J].1989,105(5).
[25]N, Holic,T, Suzuki,A, Corlu,etc.Differential expression of the rat gamma-glutamyl transpeptidase gene promoters along with differentiation of hepatoblasts into biliary or hepatocytic lineage.[J].2000,157.
[26]Guo-qing, Han,Cheng-yong, Qin,Wan-hua, Ren,etc.[Clinical impact of gamma-glutamyl transpeptidase messenger RNA subtypes on early diagnosis of hepatocellular carcinoma].[J].2002,21.
[27]Huseby NE,Mikkelsen IM,Laperche Y,etc.The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress.[J].2002,232(1).
[28]Visvikis A,Daubeuf S,Pettersen I,etc.Differential regulation of gamma-glutamyltransferase mRNAs in four human tumour cell lines.[J].2001,1568(1).
[29]M, Orlowski,A, Szczeklik.Heterogeneity of serum gamma-glutamyl transpeptidase in hepatobiliary diseases.[J].1967,15.
[30]Z Y, Tang.Hepatocellular carcinoma--cause, treatment and metastasis.[J].2001,7.