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Advance on relationship between Id protein and tumor

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 7

DOI:: 10.3969/j.issn.1009-3079.2005.07.015

Key Word:: No keyword available

Abstract： DNA结合和分化抑制剂(inhibitor of DNA binding and differentiation,Id)是螺旋-环-螺旋(helix-loop-helix,HLH)转录因子亚家族的一个成员,4个Id成员与碱性螺旋-环-螺旋(basic hehx-loop-helix,bHLH)蛋白形成二聚体,但缺乏碱性DNA结合结构域,因此,Id-bHLH异源二聚体不能结合DNA,故Id蛋白是bHLH转录因子的显性负调节子.Id蛋白也能与非HLH蛋白相互作用,如Rb、Ets、同源盒家族转录因子Pax、小鼠Id相关蛋白1(MIDA-1),并抑制其活性.现已证实Id在肿瘤细胞中通常过表达,并且与肿瘤细胞增生、分化、凋亡、侵袭等密切相关.

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