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Transcriptional regulation of collagen genes in fibrotic diseases

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 2

DOI:: 10.3969/j.issn.1009-3079.2005.02.004

Key Word:: 胶原;转录;纤维化

Abstract：肝等器官纤维化的物质基础是细胞外间质ECM的异常过度沉积,胶原蛋白是这种细胞外间质的主要成分.Ⅰ型胶原在正常肝脏中所占比例很少,但肝纤维化形成时,Ⅰ型胶原迅速增加,成为硬化的主要间质.因此,Ⅰ型胶原的研究对整个细胞外间质成分的研究具有代表性.胶原基因从本身到转录、剪接、翻译、翻译后修饰等各个环节上若发生异常,均可导致相关疾病的发生和发展.本文重点对胶原基因,特别是Ⅰ型胶原基因的转录调控、参与介导胶原基因激活的转录因子、胶原基因多态性与疾病相关性等研究进展做评述,一方面旨在揭示纤维化相关胶原基因的重要调控序列及其DNA结合蛋白,在分子水平认识病理条件下胶原基因如何被异常激活并开始高活性转录,另一方面对于建立转录水平筛选抗纤维化药物技术平台及纤维化患者的预测、个体化治疗具有深远意义.

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