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大蒜素抗肿瘤的作用机制

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 11

DOI:: 10.3969/j.issn.1009-3079.2004.11.038

Key Word:: No keyword available

Abstract：大蒜素(diallyl trisulfide,allicin)又名大蒜新素,化学名二烯丙基三硫化物,是从大蒜球茎中分离出的一种化合物,有多种生物活性,有抗真菌、抗细菌、降血酯、降血压、防治动脉粥样硬化等心血管疾病的作用,并具有良好的抗癌,防癌的作用.大蒜素的抗肿瘤机制为:(1)阻断致癌物的合成、抗突变、抗畸变;(2)对肿瘤细胞的影响:直接杀伤;抑制肿瘤细胞增生,诱导细胞周期特异性阻滞,诱导凋亡、诱导肿瘤细胞分化及对细胞通讯的影响;(3)调节机体免疫功能:包括对红细胞、巨噬细胞,T淋巴细胞、NK细胞及IL-2的调节;(4)其他:对抗肿瘤药物的增敏作用和抗耐药.研究结果显示,大蒜素确实有很好的抗中瘤作用.对大蒜素抗肿瘤作用机制的研究很多,提示了大蒜素抗肿瘤作用是通过多个途径完成的.

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