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Leptin and estrogen in pathogenesis of nonalcoholic fatty liver disease in male adults
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1009-3079.2004.08.034
- Key Word:
- No keyword available
Abstract： 目的:研究瘦素和雌激素在成年男性非酒精性脂肪肝病(NAFLD)发病中的作用.方法:采用放射免疫法(RIA)测定体检人群中肥胖合并NAFLD患者(n=29)、单纯性肥胖者(n=29)和正常对照者(n=29)血清胰岛素、雌激素和瘦素水平,同时采用稳态模型法计算胰岛素抵抗指数(HOMA-HRI).结果:空腹胰岛素水平和HOMA-IRI在对照组、肥胖组和NAFLD三组,依次升高,存在显著性差异(P＜0.05);NAFLD组瘦素水平为9.55±3.56 mg/L与肥胖组的8.07±2.92 mg/L相比较,有升高的倾向(P=0.124),这两组均显著高于对照组5.17±3.29mg/L(P＜0.05);NAFLD组雌二醇为61.84±16.21 pg/L,显著高于对照组的51.45±12.31 pg/L(P＜0.05).HOMA-IRI与瘦素显著正相关(r=0.604,P＜0.001);与雌二醇也呈显著正相关(r=0.241,P=0.02).结论:NAFLD组的HOMA-IRI和空腹胰岛素水平高于肥胖组,肥胖组高于对照组,说明胰岛素抵抗是NAFLD患者基本特征;NAFLD患者瘦素和雌二醇水平升高,提示瘦素和雌激素可能参与了其胰岛素抵抗的发生发展.
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