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Expression of apoptosis-related proteins and proliferating cell nuclear antigen during stomach canceration

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
4
DOI:
10.3969/j.issn.1009-3079.2004.04.004
Key Word:
No keyword available

Abstract: 目的:探讨凋亡相关基因p53,Bcl-2和增生细胞核抗原(PCNA)在胃癌发生中的作用以及在胃癌早期诊断中的意义.方法:采用免疫组化(LSAB)方法检测52例胃癌癌变前后组织标本的p53,Bcl-2和PCNA的表达.结果:肠上皮化生、不典型增生和胃癌的p53蛋白表达分别为27.8%,38.2%和57.7%;Bcl-2蛋白表达分别为33.3%,50.0%和65.4%;PCNALI分别为41.4±13.0,47.9±8.9和53.0±11.9.在肠型胃癌,癌前p53,Bcl-2阳性者发展到癌时仍全为阳性,无1例转阴性;在弥漫型胃癌,癌前Bcl-2阳性者到癌时有1例转阴;PCNA LI由癌前发展到癌时明显增高,在肠型胃癌差异有显著性(P<0.001).结论:在肠型胃癌发生发展过程中,p53,Bcl-2蛋白表达起重要作用,且细胞增生活性逐渐升高.

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