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肝素酶:抗肿瘤转移的新靶点
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1009-3079.2004.02.048
- Key Word:
- No keyword available
Abstract： 肝素酶(hpa)是裂解硫酸乙酰肝素蛋白多糖的惟一酶类,能破坏细胞外基质及基底膜,并参与肿瘤血管生成,与肿瘤的侵袭转移密切相关.hpa也由此逐渐成为引人注目的抗肿瘤治疗新靶点,其抑制剂的研制可望为抗肿瘤治疗开辟新的途径.本文综述了hpa的结构与功能,对肿瘤转移的促进作用与机制,以及hpa抑制剂作为抗肿瘤新药的最新研究进展.
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