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幽门螺杆菌的基因组及蛋白质组学研究进展

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 12

DOI:: 10.3969/j.issn.1009-3079.2003.12.046

Key Word:: No keyword available

Abstract：随着幽门螺杆菌26 695与J99菌株基因组测序工作的完成,人们对该菌的基因组学特点有了较清楚的认识,在此基础上,利用生物芯片、2-D电泳、质谱及生物信息学技术开展的后基因组学研究正成为Hp研究的前沿领域.本文首先对幽门螺杆菌的基因组特点及其多样性研究进行了概述,然后重点对后基因组学研究的最新进展进行了综述,特别是对当前Hp蛋白质组研究的核心技术(2-D电泳、免疫印迹、亲和层析及基质辅助激光解析/电离质谱等)的特点及其优缺点以及在Hp遗传变异、免疫靶点筛选及毒力因子确定等方面的应用进行了比较和阐述,对目前Hp的基因组和蛋白质组研究面临的问题及发展趋势也进行了展望.

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