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Expression of PKCβ1 and PKCβ2 in early gastric carcinoma

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
9
DOI:
10.3969/j.issn.1009-3079.2003.09.006
Key Word:
No keyword available

Abstract´╝Ü 目的:观察PKCβ1和PKCβ2在早期胃癌癌组织及其癌周不典型增生和肠上皮化生中的表达.方法:对42例早期胃癌胃全切标本的癌组织、癌旁不典型增生、肠上皮化生及正常胃黏膜进行PKCβ1和PKCβ2免疫组织化学染色.结果:正常胃黏膜上皮颈部散在PKCβ1阳性细胞,黏膜表面上皮细胞及幽门腺PKCβ1和PKCβ2阴性;胃底腺壁细胞和主细胞PKCβ1和PKCβ2呈强阳性.胃黏膜内淋巴滤泡中心区PKCβ1强阳性,PKCβ2阴性;相反,淋巴滤泡帽带区PKCβ1阴性,而PKCβ2强阳性.胃癌、癌旁不典型增生、肠上皮化生PKCβ1的表达明显增强,而PKCβ2的表达无明显增强,肠型胃癌PKCβ1的表达明显高于弥漫型.PKC β1的表达与早期胃癌的浸润深度无关.结论:PKC β1在胃黏膜腺上皮颈部和淋巴滤泡中心的强阳性表达提示PKC β1可能与细胞的增生活性有关;胃癌及癌前病变中PKC β1的表达增强显示PKC β1参与了胃癌的癌变过程,并可能在癌变早期发生改变.

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