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Expression of survivin protein in hepa-tocellular carcinoma tissues and its relationship with clinical pathological features and prognosis

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
4
DOI:
10.3969/j.issn.1009-3079.2003.04.009
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Abstract´╝Ü 目的:研究survivin蛋白在人肝癌组织中的表达与临床病理特征及预后的关系.方法:应用免疫组织化学染色对48例肝癌中survivin蛋白与增生细胞核抗原(PCNA)的表达情况进行检测,采用TUNEL方法检测细胞凋亡,结合临床病理特征及预后进行分析.结果:48例肝癌中survivin蛋白表达阳性率为64.6%.Edmondson分级Ⅰ-Ⅱ级患者survivin蛋白表达明显低于Ⅲ-Ⅳ级患者(39.1% vs 88.0%,P=0.013).survivin蛋白表达阳性者肝癌细胞增生凋亡比显著高于表达阴性者(1.8vs 1.1,P=0.045).survivin蛋白表达阴性患者与表达阳性患者比较,1 a生存率差异无显著意义,但3 a生存率前者显著高于后者(70.6% vs 35.5%,P=0.011).结论:survivin蛋白对破坏肝癌细胞增生凋亡平衡、促进肝癌细胞快速增生具有重要作用,survivin蛋白的表达可以作为预后不良的重要指标.

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