You Position: Home > Paper
Expression of survivin protein in hepa-tocellular carcinoma tissues and its relationship with clinical pathological features and prognosis
( views:358, downloads:0 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2003.04.009
- Key Word:
- No keyword available
Abstract： 目的:研究survivin蛋白在人肝癌组织中的表达与临床病理特征及预后的关系.方法:应用免疫组织化学染色对48例肝癌中survivin蛋白与增生细胞核抗原(PCNA)的表达情况进行检测,采用TUNEL方法检测细胞凋亡,结合临床病理特征及预后进行分析.结果:48例肝癌中survivin蛋白表达阳性率为64.6%.Edmondson分级Ⅰ-Ⅱ级患者survivin蛋白表达明显低于Ⅲ-Ⅳ级患者(39.1% vs 88.0%,P=0.013).survivin蛋白表达阳性者肝癌细胞增生凋亡比显著高于表达阴性者(1.8vs 1.1,P=0.045).survivin蛋白表达阴性患者与表达阳性患者比较,1 a生存率差异无显著意义,但3 a生存率前者显著高于后者(70.6% vs 35.5%,P=0.011).结论:survivin蛋白对破坏肝癌细胞增生凋亡平衡、促进肝癌细胞快速增生具有重要作用,survivin蛋白的表达可以作为预后不良的重要指标.
- [1]Kun Wu,Yao Li,Yan Zhao,etc.Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells[J].2002,(6).
- [2]Lian-Xin Liu,Zhi-Hua Liu,Hong-Chi Jiang,etc.Profiling of differentially expressed genes in human Gastric carcinoma by cDNA expression array[J].2002,(4).
- [3]Xiao-Zhong Guo,Xiao-Dong Shao,Min-Pei Liu,etc.Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma[J].2002,(6).
- [4]Ming-Yao Wu,Ying-Rui Liang,Xian-Ying Wu,etc.Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma and precancerous lesions[J].2002,(6).
- [5]Chang-Min Shan,Juan Li.Study of apoptosis in human liver cancers[J].2002,(2).
- [6]Islam A,Kaneko Y,Takayasu H,etc.High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma.[J].2000,19(5).
- [7]S, Jiang,M J, Song,E C, Shin,etc.Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways.[J].1999,29.
- [8]Katalinic A,Tannapfel A,Hauss J,etc.Apoptosis and proliferation in relation to histopathological variables and prognosis in hepatocellular carcinoma.[J].1999,187(4).
- [9]Naoki Hino,Toshihiro Higashi,Kazuhiro Nouso,etc.Apoptosis and proliferation of human hepatocellular carcinoma[J].1996,16(2).
- [10]Okazaki Minoru,Izawa Akiko,Kobayashi Daisuke,etc.Survivin mRNA expression in patients with breast cancer.[J].2002,22(3).
- [11]K, Yamamoto,K, Takenaka,K, Kajiyama,etc.Cell proliferation and cell loss in nodule-in-nodule hepatocellular carcinoma.[J].1900,46.
- [12]Lanzoni VP,Forones NM,Oshima CT,etc.Apoptosis, PCNA and p53 in hepatocellular carcinoma.[J].2002,49(46).
- [13]Camus E,Groyer A,Bringuier AF,etc.Overexpression of the mouse Fas gene in human Hep3B hepatoma cells overcomes their resistance to Fas-mediated apoptosis.[J].2002,36(3).
- [14]C, R?cken,S, Carl-McGrath.Pathology and pathogenesis of hepatocellular carcinoma.[J].2001,19.
- [15]Cotsonis G,Cohen C,Lawson D,etc.Hepatocellular carcinoma and markers of apoptosis (bcl-2, bax, bcl-x): prognostic significance.[J].2002,10(3).
- [16]Monden M,Umeshita K,Dono K,etc.Both cell proliferation and apoptosis significantly predict shortened disease-free survival in hepatocellular carcinoma.[J].1999,81(4).
- [17]Dong Youyi,Sui Li,Sugimoto Katsuyoshi,etc.Survivin expression in laryngeal squamous cell carcinomas and its prognostic implications.[J].2002,22(4).
- [18]Alexandra, Kalogeraki,Francesco, Garbagnati,Mario, Santinami,etc.DNA fragmentation and cell proliferation correlated with tumor grade in patients with hepatocellular carcinoma.[J].2002,96.
- [19]Y N, Park,K J, Chae,Y B, Kim,etc.Apoptosis and proliferation in hepatocarcinogenesis related to cirrhosis.[J].2001,92(11).