You Position: Home > Paper
血清中血管内皮生长因子与胃癌侵袭和转移的关系
( views:170, downloads:12 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1009-3079.2003.03.024
- Key Word:
- No keyword available
Abstract： 目的:检测胃癌患者术前血清中血管内皮生长因子(VEGF)浓度,探讨其与胃癌侵袭和转移的关系.方法:应用酶联免疫技术(ELISA法)检测51例胃癌患者和10名健康人血清中VEGF浓度;应用免疫组织化学技术检测胃癌组织中VEGF蛋白表达.结果:胃癌患者血清VEGF浓度高于健康对照(P＜0.05),与胃癌浸润深度(P＜0.05),淋巴结转移(P＜0.01),远处转移(P＜0.01),肿瘤分期(P＜0.05)及肿瘤组织学分型(P＜0.05),生长方式(P＜0.05)密切相关,与性别无关(P＞0.05).肿瘤组织VEGF蛋白表达阳性的患者血清VEGF浓度明显高于VEGF蛋白表达阴性的患者(P＜0.05).结论:血清VEGF浓度与胃癌侵袭和转移密切相关,胃癌患者血清VEGF浓度升高是其对应肿瘤组织VEGF蛋白高表达的结果.
- [1]H, Yoshiji,D E, Gomez,M, Shibuya,etc.Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer.[J].1996,56.
- [2]Kitamura, M,Toi, M,Arai, K,etc.Concentrations of vascular endothelial growth factor in the sera of gastric cancer patients.[J].1998,5(6).
- [3]J, Folkman,K, Watson,D, Ingber,etc.Induction of angiogenesis during the transition from hyperplasia to neoplasia.[J].1989,339.
- [4]Eroglu A,Kocaoglu H,Ayyildiz A,etc.Serum concentrations of vascular endothelial growth factor and nitrite as an estimate of in vivo nitric oxide in patients with gastric cancer.[J].1999,80(10).
- [5]P, Salven,H, M?np,A, Orpana,etc.Serum vascular endothelial growth factor is often elevated in disseminated cancer.[J].1997,3(5).
- [6]M, Miyake,T, Taki,S, Hitomi,etc.Correlation of expression of H/Le(y)/Le(b) antigens with survival in patients with carcinoma of the lung.[J].1992,327.
- [7]A, Kraft,K, Weindel,A, Ochs,etc.Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease.[J].1999,85(1).