幽门螺杆菌感染者胃上皮细胞凋亡与维生素C之间的关系
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1009-3079.2003.01.027
- Key Word:
- No keyword available
Abstract： 目的:研究幽门螺杆菌(Hp)感染者细胞凋亡与胃液维生素C(VitC)含量之间的关系.方法:用切口末端标记法(TUNEL)对Hp阳性的十二指肠球部溃疡(DU)、胃溃疡(GU)、癌前病变、胃癌患者以及组织学上正常的Hp阴性者各10例的胃黏膜活检组织进行细胞凋亡检测,并测定其胃液中的VitC含量.结果:细胞凋亡从Hp阳性的十二指肠溃疡→胃溃疡→癌前病变→胃癌→Hp阴性的正常组织逐渐减少,凋亡指数分别为17.5%、15.1%、9.2%、5.1%、2.5%.除胃溃疡与球部溃疡之间无统计意义外(P＞0.05),其他各组之间相互比较的差别均有统计学意义(P＜0.05).VitC含量从正常组织(34.8 ug/m1)→十二指肠溃疡(18.6 ug/m1)→胃溃疡(16.5 ug/m1)→癌前病变(11 ug/m1)→胃癌(6.2 ug/m1)逐渐下降;除DU与GU组之间无统计意义外,其他各组之间相互比较的差别均有统计学意义(P＜0.01).HP根除以后细胞凋亡显著下降,VitC含量明显增高至正常水平.Hp阳性的十二指肠溃疡、胃溃疡细胞凋亡指数与VitC含量呈显著负相关(P＜0.05),而癌前病变组和胃癌组,细胞凋亡指数与VitC含量之间均无显著相关性(P＞0.05).结论:上述结果提示(1)Hp感染可能诱导胃上皮细胞凋亡,并使胃液VitC含量减少,使机体失去对VitC的保护作用,这可能是Hp导致胃癌的机制之一,补充VitC可能有助于预防胃癌的发生;(2)在Hp感染早期,胃液VitC含量的减少可能促进胃上皮细胞凋亡.因此,根除Hp使胃腔VitC浓度升高,以减少细胞凋亡可能有助于预防胃癌的发生.
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