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Changes of serum level of IL-15, IL-18 and sTNF-1R in patients with acute pancreatitis

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
1
DOI:
10.3969/j.issn.1009-3079.2003.01.016
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No keyword available

Abstract´╝Ü 目的:本实验通过测定急性胰腺炎(AP)患者血清白介素-15(IL-15)、白介素-18(IL-18)及可溶性肿瘤坏死因子受体-1(sTNF-1R)的水平,探讨他们与AP的关系.分析他们之间的相关性.研究对重症急性胰腺炎(SAP)的发生可能有预测作用的指标.探讨炎性递质在急性胰腺炎发病机制中的作用.方法:选择AP患者26例,按照急性胰腺炎的临床诊断及分级标准分组,其中SAP患者7例,轻型急性胰腺炎(MAP)患者19例,正常对照组10例.用ELISA法检测血清IL-15、IL-18及STNF-1R浓度.结果:血清中IL-15、IL-18及sTNF-1R浓度在MAP和SAP两组患者之间存在显著差异,SAP组明显高于MAP组,SAP同MAP组比较:IL-18:78±15 vs 28±13ng/l,(P<0.01);IL-15:42±19 vs 6±2 ng/l,(P<0.01);sTNF-1R:6 327±3 655 vs 832±329 ng/l,(P<0.01);sTNF-1R在SAP和MAP组显著高于正常对照组,SAP同对照组比较6327±3 655 vs 545±123 ng/l,(P<0.01);MAP同对照组比较832±329 vs 545±123ng/l,(P<0.01);IL-15同IL-18有相似的结果,即MAP组显著低于正常对照组,MAP同对照组比较:IL-18:28±13 vs 66±10 ng/l,(P<0.01);IL-15:6±2 vs 53±13 ng/l,(P<0.01);SAP组同正常对照组之间无显著性差异(P>0.05).轻型急性胰腺炎患者血清sTNF-1R同IL-18呈显著正相关(r=0.98,P<0.01);sTNF-1R同IL-15呈显著正相关,(r=0.823,P<0.01);IL-18同IL-15呈显著正相关,(r=0.95,P<0.01).重型急性胰腺炎患者血清IL-18同IL--15呈显著正相关,(r=0.906,P<0.01);sTNF-1R同IL-15呈显著正相关,(r=0.93,,P<0.01);sTNF-1R同IL-18呈显著正相关,(r=0.953,P<0.01).结论:血清IL-15、IL-18及sTNF-1R参与了急性胰腺炎的炎症反应过程,可能是预测急性胰腺炎的严重程度的指标.

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