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Hypoxic signal transduction in tumour cells

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 12

DOI:: 10.3969/j.issn.1009-3079.2002.12.023

Key Word:: No keyword available

Abstract：肿瘤细胞的缺氧信号通路是一个受多种因素调控的十分复杂的过程.缺氧通过直接或间接调节细胞内氧化型/还原型谷胱甘肽(GSSG/GSH)的方式作用于氧感受器分子,使其构象发生改变,并通过第二信使-活性氧族(ROS)与激酶系统发生联系,激活某些激酶系统,促使缺氧特异生转录因子-缺氧诱生因子-1 α(HIF-1 α)的磷酸化并与HIF-Iβ结合而形成一个完整的HIF-I转录复合体,从而与相应靶基因上的缺氧反应元件(HRE)结合,促进基因的表达.充分了解肿瘤细胞的缺氧信号传导通路必将有助于通过对这些信号传导通路进行干预,达到预防和治疗恶性肿瘤的目的.

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