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Treatment of GI tract cancer with arsenic trioxidate to induce tumor cell apoptoses
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1009-3079.2002.06.025
- Key Word:
- No keyword available
Abstract： 三氧化二砷(As2O2)中药名砒霜,祖国医学应用于临床有悠久的历史,1970年,许多学者开始研究其抗癌作用,经过多年的实验室研究和临床应用,As2O3在抗癌方面取得了肯定的疗效,首先用于急性早幼粒性白血病,其主要机制为诱导肿瘤细胞凋亡.近几年来许多学者研究用其诱导肿瘤凋亡治疗消化道肿瘤,已应用于肝癌的治疗,现将As2O3对消化道肿瘤基础研究和临床应用作以简要综述.
- [1]郁宝铭,崔巍,陆爱国,等.三氧化二砷诱导的结肠癌细胞凋亡及其与细胞周期的关系[J].2000,(2).
- [2]谭继宏,涂水平,蒋晓华,等.氧化砷诱导胃癌细胞凋亡的实验研究[J].2000,(1).
- [3]陈洪,秦叔逵,陈惠英.三氧化二砷抗肝癌作用的实验研究[J].2000,(1).
- [4]姚和瑞,谢德荣,向燕群,等.三氧化二砷抑制NCI-H69肺癌细胞增殖的初步研究[J].2000,(5).
- [5]高虎,张方信,梁君蓉.药物诱导细胞凋亡与胃癌治疗[J].2000,(7).
- [6]沈玉雷,陈国强,蔡循.谷胱甘肽合成酶抑制剂加强三氧化二砷的凋亡诱导效应[J].1999,(4).
- [7]黄晓珺,周宇红,蔡循,等.三氧化二砷对多发性骨髓瘤细胞的影响[J].2000,(6).
- [8]詹俊,谢德荣,姚和瑞,等.三氧化二砷诱导大肠癌细胞株SW620凋亡[J].2001,(2).
- [9]蔡循,陈国强,陈竺,等.三氧化二砷治疗肿瘤的机制研究[J].2001,(2).
- [10]顾琴龙,李宁丽,林言箴.三氧化二砷对人胃癌细胞诱导分化的实验[J].2000,(6).
- [11]陈惠英,刘文虎,秦叔逵.三氧化二砷对肝癌细胞株凋亡的诱导作用[J].2000,(5).
- [12]高虎,陈嘉屿,余西林.药物诱导细胞凋亡治疗肝癌[J].2001,(6).
- [13]Y M, Li,J D, Broome.Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.[J].1999,59(4).
- [14]谭立军,史桂英,石学耕,等.三氧化二砷对人食管癌细胞株凋亡的诱导作用[J].1999,(2).
- [15]J F, Kerr,C M, Winterford,B V, Harmon.Apoptosis. Its significance in cancer and cancer therapy.[J].1994,73(8).
- [16]L C, Stephens,N R, Hunter,K K, Ang,etc.Development of apoptosis in irradiated murine tumors as a function of time and dose.[J].1993,135.
- [17]谭立军,陈新宇,张岚,等.DMSO和AS_2O_3对人食管癌细胞增殖的抑制作用[J].1999,(1).
- [18]Naoki Hino,Toshihiro Higashi,Kazuhiro Nouso,etc.Apoptosis and proliferation of human hepatocellular carcinoma[J].1996,16(2).
- [19]Zhu Q,Jia PM,Chen SJ,etc.Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia.[J].2000,14(2).
- [20]G Q, Chen,J, Zhu,X G, Shi,etc.In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins.[J].1996,88.
- [21]Hug H,Krammer PH,Galle PR,etc.Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.[J].1997,99(3).
- [22]倪建华,陈国强.砷的生物学作用及其在临床上的应用前景[J].1997,(4).
- [23]Nakamura S,Zhang W,Takeshita K,etc.The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.[J].1998,12(9).
- [24]D L, Evans,C, Dive.Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytes.[J].1993,53.
- [25]秦叔逵,陈洪,陈惠英,等.三氧化二砷诱导人肝癌细胞株凋亡的初步研究[J].1998,(2).