You Position: Home > Paper
Cell apoptosis and ulcerative colitis
( views:114, downloads:1 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2002.04.019
- Key Word:
- No keyword available
Abstract： @@ 0引言溃疡性结肠炎(ulcerative colitis,UC)是原因不明的慢性肠道炎症性疾病,目前人们认为他的发病机制是多因素相互作用的结果,包括环境因素、遗传因素和免疫因素等,即感染、饮食等环境因素作用于遗传易感的人群,使肠免疫反应过度亢进,导致肠黏膜损伤而发病[1].但UC的病因仍然不清楚.近年来,UC与细胞凋亡的关系受到了人们的关注,一些结果显示细胞凋亡可能在UC的发病中起重要的作用,下面我们从细胞凋亡的角度来探讨一下UC的发病机制.
- [1]江学良,权启镇,孙自勤,等.溃疡性结肠炎患者淋巴细胞凋亡调控蛋白的表达[J].1999,(10).
- [2]江学良,权启镇,陈桂荣,等.凋亡调控蛋白在溃疡性结肠炎活检组织中的表达[J].2000,(1).
- [3]夏冰.炎症性肠病的病因与发病机制[J].2001,(3).
- [4]J, O'Connell,M W, Bennett,K, Nally,etc.Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis.[J].2000,185(3).
- [5]N, Arai,H, Mitomi,Y, Ohtani,etc.Enhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1/CIP1 expression in ulcerative colitis.[J].1999,12.
- [6]Monica Boirivant,Marco Marini,Gabriella Di Felice,etc.Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis[J].1999,116(3).
- [7]Makiyama K,Kobayashi N,Nakane PK,etc.Apoptosis of crypt epithelial cells in ulcerative colitis.[J].1996,180(2).
- [8]S, Bregenholt,T R, Petersen,M H, Claesson.The majority of lamina propria CD4(+) T-cells from scid mice with colitis undergo Fas-mediated apoptosis in vivo.[J].2001,78(1).
- [9]Ueyama,H,Kiyohara,T,Sawada,N,etc.High Fas ligand expression on lymphocytes in lesions of ulcerative colitis (see comments)[J].1998,43(1).
- [10]J Strater,I Wellisch,S Riedl,etc.CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis[J].1997,113(1).
- [11]Søren Bregenholt,Jörg Reimann and,Morgens H. Claesson.Proliferation and apoptosis of lamina propria CD4<sup>+</sup> T cells from scid mice with inflammatory bowel disease[J].1998,28(11).
- [12]S, Krajewski,M, Krajewska,A, Shabaik,etc.Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.[J].1994,145.
- [13]O'Neill A,O'Connell PR,Brannigan AE,etc.Neutrophil apoptosis is delayed in patients with inflammatory bowel disease.[J].2000,13(5).
- [14]Boirivant M,Neurath MF,Finotto S,etc.Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.[J].2001,22(1).
- [15]Colpaert S,D'Haens GR,Rutgeerts P,etc.IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production.[J].2000,164(7).
- [16]M Sandoval,X Liu,EE Mannick,etc.Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine[J].1997,113(5).
- [17]Ina K,Kusugami K,Hosokawa T,etc.Increased mucosal production of granulocyte colony-stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease.[J].1999,14(1).
- [18]Watson AJM.,Merritt AJ.,Loh DY.,etc.Differential Expression of Bcl-2 in Intestinal Epithelia - Correlation with Attenuation of Apoptosis in Colonic Crypts and the Incidence of Colonic Neoplasia[J].1995,108(Pt.6).
- [19]C B, Thompson.Apoptosis in the pathogenesis and treatment of disease.[J].1995,267.
- [20]Ohtsuka K,Hasegawa K,Suzuki K,etc.Fas/Fas ligand expression and characteristics of primed CD45RO+ T cells in the inflamed mucosa of ulcerative colitis.[J].2000,35(12).