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Progress in the study of proteins interacting with hepatitis B viral proteins
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1009-3079.2002.02.024
- Key Word:
- No keyword available
Abstract： @@ 0 引言随着基因组测序工作的完成,后面就是研究基因的功能,其中基因表达蛋白质的功能的研究尤为重要,因为基因是通过蛋白质起作用的.蛋白质与蛋白质之间的相互作用揭示了蛋白质功能的物理基础之一,即蛋白质起作用是通过与另一蛋白质进行物理接触而完成.大家知道乙型肝炎病毒(HBV),对人体有着广泛的作用,如引起人免疫紊乱、慢性肝炎、肝硬化、肝肿瘤发生,治疗效果不佳[1-9 ],但是他们是如何作用的目前不是太清楚,但是可以肯定其中具有蛋白质-蛋白质之间的相互作用.1990年代以来一系列遗传、生化方法特别是酵母双杂交技术等进展,为研究HBV与人体蛋白质之间的相互作用打下了基础.HBV有四个结构蛋白开放读码框架,S、C、P、X编码前-S1、前-S2、HBsAg、HBcAg、HBeAg、病毒多聚酶、和HBxAg,其中HBxAg作用复杂有反式激活作用[10].但是其结构中没有DNA结合域,推测可能和蛋白质之间的相互作用有关,研究比较多.其次是前-S1等.目前鉴定的与HBV相互作用的蛋白质有十几种
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