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Platelet-activating factor and onset and treatment of acute pancreatitis

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 8

DOI:: 10.3969/j.issn.1009-3079.2001.08.032

Key Word:: 血小板活化因子;胰腺炎,急性坏死性/病因学;综述文献

Abstract： @@ 0引言急性胰腺炎(acute pancreatitis,AP)的发病机制至今仍未完全阐明[1-14].自1988年Rindernecht提出AP的"白细胞系统过度激活学说"后,大量的实验和临床研究证实细胞因子及炎性递质在AP的发生发展中起重要作用[15-34],其中炎性递质血小板活化因子(platelet-activating factor,PAF)被认为是AP时的关键性炎性递质.PAF是一种以前体形式储于细胞膜内的磷脂分子,为膜脂的结构成分,是强力的脂质炎性递质,其化学结构为1-O-烷基-2乙酰基-Sn-甘油-3磷脂酰胆碱,Mr约为500.PAF受体(PAF-R)属于G蛋白偶联受体家族[35-39],主要分布在大多数细胞膜上,包括血小板、白细胞和内皮细胞等,最近又证实细胞内微粒体上也存在PAF-R,一般均有两个特异性结合位点.

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