You Position: Home > Paper
多原发大肠癌细胞增殖背景
( views:174, downloads:12 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2001.04.028
- Key Word:
- 大肠肿瘤;多原发癌;非整倍体;免疫组化
Abstract： @@ 大肠癌是严重威胁人类健康的恶性肿瘤之一[1-22].统计资料表明,在世界范围内大肠癌的发病率在恶性肿瘤中已升至第三位.与欧美国家相比,我国大肠癌的发病率也呈逐年上升趋势,且发病年龄明显提前,成为威胁人们健康的主要疾病.多原发大肠癌发生率占大肠癌的4%～13%近年来,多原发大肠癌发病率有增多趋势,国外文献报告为4%～13.8%[23],国内报告为2.4%～15.7%[24].与单发大肠癌相似,多原发大肠癌起病隐匿,早期几乎无任何特征性临床表现,多数确诊时已届晚期.多原发大肠癌细胞增殖背景如何,与单发大肠癌相比是否有更高的恶性行为,目前并不十分清楚.本文旨在进一步分析多原发大肠癌细胞增殖状态,探寻早期确诊多原发大肠癌的方法,对指导大肠癌手术治疗,提高患者5年生存率具有重要意义.
- [1]Chen Yang Ji,DR Smith,HS Goh.The role and prognostic significance of p53 mutation in colorectal carcinomas[J].2000,(3).
- [2]Xu QW,Li YS,Zhu HG.Relationship between expression P53 protein, PCNA and CEA in colorectal cancer and lymph node metastasis[J].1998,(3).
- [3]Qi Cai,Hong Fen Lu,Meng Hong Sun,etc.Expression of two CD44 variant proteins (v3 and v6) in human colorectalcarcinoma and its relevance for prognosis[J].2000,(3).
- [4]莫善兢,郑兆尧,李澍,等.大肠癌病人的多原发恶性肿瘤[J].1985,(4).
- [5]WANG Li,LU Wei,CHEN Yuan-Gen,etc.Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display[J].1999,(6).
- [6]郑树主编.中国癌症研究进展 （三）[M].1998.
- [7].Identity of the proliferating cell nuclear antigen and cyclin[J].1984,309(5966).
- [8]Ma LS,Pan BR.Strengthen international academic exchange and promote development of gastroenterology[J].1998,(1).
- [9]ZHOU Zheng-Fen,YUAN Shi-Zhen.Prognostic value of silver-stained nucleolar organizer regions in colorecetal carcinoma[J].1995,1(1).
- [10]Feng S,Wang YY,Song JD.Relationship between expression of laminin and pathological features in human colorectal carcinoma[J].1998,(3).
- [11]ZHUANG Xiao-Qiang,WANG Xiao-Huai,LAI Ri-Quan,etc.Oncoprotein expression and inhibition of apoptosis during colorectal tumorigenesis[J].1996,2(1).
- [12]HE Shuang-wu,SHEN Kang-qiang,HE Yu-jun,etc.Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma[J].1999,(5).
- [13]R, Fante,L, Roncucci,M G, Tamassia,etc.Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma.[J].1996,77(10).
- [14]ZHANG Jing,LAI Mao-de,Chen Jian.Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa[J].1999,(5).
- [15].Microsatellite Instability, Mmr Gene Expression and Proliferation Kinetics in Colorectal Cancer with Famillial Predisposition[J].2000,(6).
- [16]CHEN Da-Wei,WANG Yuan-He,CHEN Xue-Yun,etc.Clinical significance of immunohistochemical study of P53 protein in colorectal carcinoma[J].1996,2(1).
- [17]Wang Yi-Xing.Clinical significance of changes of perioperative T cell and expression of its activatedantigen in colorectal cancer patients[J].1999.
- [18]D, Schwartz,B F, Banner,D L, Roseman,etc.Origin of multiple "primary" colon carcinomas. A retrospective flow cytometric study.[J].1986,58(9).
- [19]Martin Lipkin.Update of preclinical and human studies of calcium and colon cancer prevention[J].1999,(6).