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急性胰腺炎的病因、病理
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2001.04.012
- Key Word:
- 急性胰腺炎;病理生理;细胞因子;胆道疾病;酗酒;创伤
Abstract： @@ 急性胰腺炎(acute pancreatitis, AP)是指在胰酶作用下胰腺组织被自身消化而引起的化学性炎症.有多种病因可引起AP,每种病因似乎最终都会过早激活胰酶及被激活的胰酶滞留在胰腺内引起胰腺组织的破坏.胰腺组织的破坏立即引起细胞因子的释放和补体系统的激活,这些炎性分子随即吸引更多的炎细胞聚集,进而释放更多的细胞因子及其他活性物质如:自由基、激肽、NO等.这些因子使炎症反应更趋剧烈,形成级联反应和恶性循环.AP引起的局部改变有水肿、出血、组织坏死、细胞凋亡等,全身症状有休克、发热、DIC、多器官功能障碍综合征等.
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