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幽门螺杆菌尿素呼气试验的临床应用

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 7

DOI:: 10.3969/j.issn.1009-3079.2000.07.016

Key Word:: 螺杆菌,幽门;螺杆菌感染/诊断;尿素酶;同位素标记;呼吸试验;仪器和设备

Abstract： @@ 幽门螺杆菌(Helicobacterpylori,Hp)感染与消化性溃疡、慢性胃炎、胃癌、胃MALT淋巴瘤等有关,尿素酶依赖的检测方法是Hp重要的诊断手段之一,其中尿素呼气试验(urea breath test,UBT)为真正的非侵入性检测、简单方便,敏感性和特异性高,重复性好,易被医患所接受.13C-尿素呼气试验(13C-UBT)是1987年建立的,1996年获美国FDA批准,但13C-尿素和检测仪器(质普仪)价格昂贵,难以普及,故Marshall 于1991年又建立了14C-尿素呼气试验(14C-UBT),希望在14C-尿素价格较低和β-液测定仪器已经普及的基础上广泛推广使用,以后大量研究表明微量14C-尿素进入人体不致影响机体和环境,1997年美国FDA也批准其用于临床.现就UBT的基本原理、基本方法、临床应用范围和评价、影响因素和对人体的辐射影响等作一综述.

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