Paper - WANFANG MED ONLINE

You Position: Home > Paper

Role of Tight Junctions and Their Protein Expression in Atopic Dermatitis

( views:0, downloads:0 )

Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 1

DOI:: 10.1097/JD9.0000000000000114

Key Word:: atopic dermatitis;tight junctions;claudin;atopic dermatitis;tight junctions;claudin

Abstract： Atopic dermatitis (AD) is a chronic inflammatory skin disease with xerosis, itchiness, as well as interconnection with immunoglobulin E (Ig E), mediated foods including airborne allergies. AD is not only related to the diminished stratum corneum barrier but also presents with an unusual expression of tight junctions (TJs) proteins. TJ barrier dysfunction leads to impairment in the stratum corneum (SC) barrier. The significant role of TJs in the epidermal barrier as indicated by Claudin-1 (Cldn-1) deficient mice that undergo high transepidermal water loss (TEWL) and skin dehydration. In atopic dermatitis, downregulation of Cldn-1 was observed due to inflammation. Still, a lack of distinct understanding exists in considering tight junction barrier impairment as a cause or outcome in atopic dermatitis. This review summarizes TJs main role in skin barrier function and TJ proteins (TJPs) expression observed in AD patients.

Reference

[1]Baesler, Katja,Brandner, Johanna M..Tight junctions in skin inflammation[J].2017,469(1).
[2]Kyeong Eun, Hyung,Soo Jeong, Kim,Ye Won, Jang,etc.Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response.[J].2017,21(3).
[3]Suzuki, Koya,Furuta, Yasuhide,Tokumasu, Reitaro,etc.Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis[J].2016,113(28).
[4]Yoshida,K.,Yokouchi,M.,Nagao,K.,etc.Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis[J].2013,71(2).
[5].Barrier Function of the Skin: “La Raison d'Être” of the Epidermis[J].2003,121(2).
[6]Werfel, Thomas,Allam, Jean-Pierre,Biedermann, Tilo,etc.Cellular and molecular immunologic mechanisms in patients with atopic dermatitis[J].2016,138(2).
[7]Takashi, Kojima,Mitsuru, Go,Ken-ichi, Takano,etc.Regulation of tight junctions in upper airway epithelium.[J].2013,2013.
[8]Kubo, Terufumi,Sugimoto, Kotaro,Kojima, Takashi,etc.Tight junction protein claudin-4 is modulated via Delta Np63 in human keratinocytes[J].2014,455(Pt.3/4).
[9]Luz S. Fonacier,Stephen C. Dreskin,Donald Y.M. Leung.Allergic skin diseases[J].2010,125(Supplement 2).
[10]Itoh M,Tsukita S,Furuse M.Multifunctional strands in tight junctions.[J].2001,2(4).
[11]Hirasawa Y,Takai T,Nakamura.Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.[J].2010,130(2).
[12].The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies[J].2017,139(Supplement).
[13]Olivry, Thierry,Dunston, Stanley M..Expression patterns of superficial epidermal adhesion molecules in an experimental dog model of acute atopic dermatitis skin lesions[J].2015,26(1).
[14]Furuse Mikio,Hata Masaki,Furuse Kyoko,etc.Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice.[J].2002,156(6).
[15]Hamilton, Jennifer D.,Suarez-Farinas, Mayte,Dhingra, Nikhil,etc.Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis[J].2014,134(6).
[16]Stacey L. Kolar,J. Antonio Ibarra,Frances E. Rivera,etc.Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence‐determinant stability[J].2013,2(1).
[17]Takuo, Yuki,Megumi, Tobiishi,Ayumi, Kusaka-Kikushima,etc.Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.[J].2016.
[18]Teruaki, Nakatsuji,Tiffany H, Chen,Saisindhu, Narala,etc.Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis.[J].2017,9(378).
[19]Czarnowicki, Tali,Malajian, Dana,Khattri, Saakshi,etc.Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer[J].2016,137(4).
[20]Matthew G,Brewer,Takeshi,Yoshida,Fiona I,Kuo,etc.Antagonistic Effects of IL-4 on IL-17A-Mediated Enhancement of Epidermal Tight Junction Function.[J].2019,20(17).
[21]Sugawara,T.,Iwamoto,N.,Akashi,M.,etc.Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice[J].2013,70(1).
[22]Robert Gruber,Christian Börnchen,Katharina Rose,etc.Diverse Regulation of Claudin-1 and Claudin-4 in Atopic Dermatitis[J].2015,185(10).
[23]Suarez-Farinas, Mayte,Ewald, David A.,Krueger, James G.,etc.RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications[J].2015,135(5).
[24]Bingjie Wang,Brian J. McHugh,Ayub Qureshi,etc.IL-1β-Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2[J].2017,137(1).
[25]De Benedetto A,Rafaels NM,McGirt LY,etc.Tight junction defects in patients with atopic dermatitis.[J].2011,127(3).
[26]Kim, Ha-Jung,Cronin, Megan,Ahrens, Kim,etc.A comparative study of epidermal tight junction proteins in a dog model of atopic dermatitis[J].2016,27(1).
[27].The cutaneous innate immune response in patients with atopic dermatitis[J].2013,131(2).
[28]Morita K,Miyachi Y,Furuse M.Tight junctions in epidermis: from barrier to keratinization.[J].2011,21(1).
[29]Kolosov, Dennis,Bui, Phuong,Chasiotis, Helen,etc.Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: A review[J].2012,184(3).
[30]Yokouchi, Mariko,Kubo, Akiharu,Kawasaki, Hiroshi,etc.Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum[J].2015,77(1).
[31]Manisha Notay,Negar Foolad,Alexandra R. Vaughn,etc.Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases[J].2017,18(6).
[32]Melino G,Candi E,Vanbokhoven H,etc.P63, a Story of Mice and Men.[J].2011,131(6).
[33]Kirschner,N.,Rosenthal,R.,Furuse,M.,etc.Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes[J].2013,133(5).
[34]O'Neill CA,Garrod D.Tight junction proteins and the epidermis.[J].2011,20(2).
[35]Feldman GJ,Mullin JM,Ryan MP.Occludin: Structure, function and regulation.[J].2005,57(6).
[36].Occludin is involved in adhesion, apoptosis, differentiation and Ca2+-homeostasis of human keratinocytes: implications for tumorigenesis.[J].2017.
[37]Kuo,I.-H.,Carpenter-Mendini,A.,Yoshida,T.,etc.Activation of epidermal toll-like receptor 2 enhances tight junction function: Implications for atopic dermatitis and skin barrier repair[J].2013,133(4).
[38]Yu, Ho-Sung,Kang, Mi-Jin,Kwon, Ji-Won,etc.Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE[J].2015,135(3).
[39]Piontek J,Winkler L,Haseloff RF,etc.Structure and function of claudins[J].2008,1778(3).
[40]Nakajima, Misaki,Nagase, Shotaro,Iida, Manami,etc.Claudin-1 Binder Enhances Epidermal Permeability in a Human Keratinocyte Model[J].2015,354(3).
[41]Teruaki Nakatsuji,Richard L Gallo.Antimicrobial peptides: old molecules with new ideas.[J].2012,132(3 Pt.2).
[42]Kiatsurayanon,C.,Niyonsaba,F.,Smithrithee,R.,etc.Host defense (antimicrobial) peptide, human β-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes[J].2014,134(8).