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Research Progress of MicroRNAs and Related Factors in the Pathogenesis of Lichen Planus

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 3

DOI:: 10.1097/JD9.0000000000000078

Key Word:: lichen planus;pathogenesis;microRNAs;lichen planus;pathogenesis;microRNAs

Abstract： More evidences show that microRNAs play an important role in the pathogenesis of inflammation and autoimmune diseases including Lichen planus, and are an attractive therapeutic target. MicroRNA family plays an important role in the regulation of gene expression, which involves cell proliferation, apoptosis, growth, differentiation and metabolism, vascularization, immune response and other biological processes. The changes of expression profile and expression level are closely related to the occurrence and development of many diseases, such as tumor, inflammatory disease and autoimmune disease relevant. However, there are few reports on microRNA in the pathogenesis of LP. This review summarizes the research advance of microRNAs (microRNAs -137, microRNAs -125b, microRNAs -138, microRNAs-27b, microRNAs -203) and their downstream proteins in LP.

Reference

[1]化红霞,白莉.扁平苔藓皮损区p53、bcl-2、c-myc基因的表达及意义[J].2007,(2).
[2]Pivarcsi A,Sonkoly E,Nagy N,etc.MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.[J].2011,131(7).
[3]杜杰,王君,赵涵,等.MMP-9,TIMP-1及ETS-1在扁平苔藓中的表达[J].2015,(6).
[4]Aihua Zhao~(a,1),Quan Zeng~(b,etc.MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression[J].2012,(1).
[5]Junjun Chen,Guanhuan Du,Yuzhou Chang,etc.Downregulated miR‐27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus[J].2019,48(4).
[6]Hong,Zheng,Chao,Zhou,Xiao,Lu,etc.DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathway.[J].2018,10.
[7]Dario Di,Stasio,Laura,Mosca,Alberta,Lucchese,etc.Salivary mir-27b Expression in Oral Lichen Planus Patients: A Series of Cases and a Narrative Review of Literature.[J].2019,19(31).
[8]Shen, Zhengyu,Zhang, Chenping,Zhou, Zengtong,etc.Altered expression of interleukin-17A and its targeting microRNAs in oral lichen planus: a pilot study[J].2016,122(5).
[9]Wang, Jing,Luo, Hong,Xiao, Yan,etc.miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3 K/Akt/mTOR pathway[J].2016,80.
[10]Brcic, I.,Ranogajec, I.,Puzovic, V.,etc.Prognostic values of ETS-1, MMP-2 and MMP-9 expression and co-expression in breast cancer patients[J].2014,61(4).
[11]Li, Jing,Hui, Liang,Kang, Qianyan,etc.Down-regulation of microRNA-27b promotes retinal pigment epithelial cell proliferation and migration by targeting Nox2[J].2018,214(7).
[12]Dong,C.,Tang,H.,Wang,Q.,etc.Downregulation of microRNA-138 enhances the proliferation, migrationand invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9[J].2013,29(5).
[13]?awicki, S?awomir,Szmitkowski, Maciej,Zajkowska, Monika,etc.Therapy of psoriasis with narrowband ultraviolet-B light influences plasma concentrations of MMP-2 and TiMP-2 in patients.[J].2016.
[14]Giuseppe Derosa,Davide Romano,Lucio Bianchi,etc.The effects of canrenone on inflammatory markers in patients with metabolic syndrome[J].2015,47(1).
[15]Wahlin,Y.B.,Gu,X.,Danielsson,K.,etc.Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus[J].2012,41(1).
[16]Farzan,Solimani,Robert,Pollmann,Thomas,Schmidt,etc.Therapeutic Targeting of Th17/Tc17 Cells Leads to Clinical Improvement of Lichen Planus.[J].2019,10.
[17]Singh, Pratyush,Grover, Jasleen,Byatnal, Aditi Amit,etc.Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus - an immunohistochemical study with supportive histochemical analysis[J].2017,46(5).
[18]刘青,吴织芬,金岩,等.ETS-1在口腔扁平苔藓中的表达研究[J].2005,(2).
[19]Takekoshi S,Shimizu M,Kajiwara H,etc.Expression of hypoxia inducible factor-1alpha (HIF-1alpha) and glucose transporter-1 (GLUT-1) in ovarian adenocarcinomas: difference in hypoxic status depending on histological character.[J].2008,19(1).
[20]王夏夏,唐国瑶,孙红英.缺氧对口腔扁平苔藓角质形成细胞增殖及缺氧诱导因子1α、血管内皮生长因子、基质金属蛋白酶9表达的影响[J].2015,50(2).
[21]Chen, Yao,Cao, Ke,Wang, Shaohua,etc.MicroRNA-138 suppresses proliferation, invasion and glycolysis in malignant melanoma cells by targeting HIF-1 alpha[J].2016,11(6).
[22]Kumaran, Muthu Sendhil,Bishnoi, Anuradha,Srivastava, Niharika,etc.Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus[J].2019,311(7).
[23]El-Rifaie, A. A.,Rashed, L. A.,Doss, R. W..The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus[J].2015,40(8).
[24]Zhou, Wei,Zhou, Weimin,Zeng, Qingzhong,etc.MicroRNA-138 inhibits hypoxia-induced proliferation of endothelial progenitor cells via inhibition of HIF-1 alpha-mediated MAPK and AKT signaling[J].2017,13(3).
[25]Wang, Hui,Guan, Xiaobing,Luo, Zhenhua,etc.The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus[J].2018,47(4).
[26]Aghbari, Sana Maher Hasan,Gaafar, Soheir Mohamed,Shaker, Olfat Gamil,etc.Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients[J].2018,310(3).
[27]Zhang Y,Du ZM,Wu QL,etc.miR-125b Is Methylated and Functions as a Tumor Suppressor by Regulating the ETS1 Proto-oncogene in Human Invasive Breast Cancer.[J].2011,71(10).
[28]Zhengyu Shen,Xuemin Shen,Jinqiu Feng,etc.Immunoexpression of Interleukin-22 and Interleukin-23 in Oral and Cutaneous Lichen Planus Lesions: A Preliminary Study[J].2013,(Pt.5).
[29]A. A. El‐Rifaie,L. A. Rashed,R. W. Doss,etc.MicroRNAs in cutaneous lichen planus[J].2017,42(8).
[30]Tang,G.-Y.,Zhou,Y.-M.,Wang,Y.-F.,etc.Altered microRNA expression profile with miR-27b down-regulation correlated with disease activity of oral lichen planus[J].2012,18(3).
[31]Junjun Chen,Yufeng Wang,Guanhuan Du,etc.Down‐regulation of miRNA‐27b‐3p suppresses keratinocytes apoptosis in oral lichen planus[J].2019,23(6).
[32]Shuming, Lu,Zhuqing, Zhang,Meiru, Chen,etc.Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP-2 and MMP-9 expression via the p38MAPK signaling pathway.[J].2017,14(6).
[33]Roy,S.S.,Basu,M.,Ghosh,S..ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3[J].2012,287(18).
[34]Shen, Zhengyu,Du, Guanhuan,Zhou, Zengtong,etc.Aberrant expression of interleukin-22 and its targeting microRNAs in oral lichen planus: a preliminary study[J].2016,45(7).
[35]Aghbari, Sana Maher,Zayed, Shaimaa Omar,Shaker, Olfat Gamil,etc.Evaluating the role of tissue microRNA-27b as a diagnostic marker for oral lichen planus and possible correlation with CD8[J].2019,48(1).
[36]Sung-Rae Kim,Tae-Kil Eom,Hee-Guk Byun.Inhibitory effect of the carnosine-gallic acid synthetic peptide on MMP-2 and MMP-9 in human fibrosarcoma HT1080 cells[J].2014,20(9).
[37]Zhang, Jian,He, Jing,Zhang, Le.The down-regulation of microRNA-137 contributes to the up-regulation of retinoblastoma cell proliferation and invasion by regulating COX-2/PGE2 signaling[J].2018,106.
[38]Aghbari, Sana Maher Hasan,Abushouk, Abdelrahman Ibrahim,Shakir, Olfat Gamil,etc.Correlation between tissue expression of microRNA-137 and CD8 in oral lichen planus[J].2018,22(3).
[39]Ghallab, Noha A.,Kasem, Rehab Fawzy,Abd El-Ghani, Safa Fathy,etc.Gene expression of miRNA-138 and cyclin D1 in oral lichen planus[J].2017,21(8).