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Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma

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International Journal of Dermatology and Venereology
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Abstract´╝Ü IntroductionCutaneous squamous cell carcinoma (CSCC) is the secondmost common non-melanoma skin cancer after basal cell carcinoma, accounting for 20% of all cutaneous malignancies. CSCC originates from epidermal keratinocytes or adnexal structures such as eccrine glands or pilosebaceous units.1 According to several studies focused on Caucasian populations in Europe, the USA and Australia, about 15– 35 per 100,000 individuals are diagnosed with CSCC each year, and the incidence of CSCC is expected to increase by 2%–4% per year.2 The incidence of primary CSCC has increased by 50%–300% globally, especially amongst Caucasian populations in New Zealand, Australia, and North America over the last 3 decades.

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