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Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 3

DOI:: 10.1097/JD9.0000000000000030

Key Word:: No keyword available

Abstract： IntroductionCutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20％-50％ of skin cancers and currently has an increasing incidence in the United States.2 Ultraviolet (UV)solar radiation is the primary risk factor for the development of CSCC,and the cumulative exposure received over a lifetime plays a major role in this development.3 Mutations in the p53 gene are the most common genetic abnormalities,causing nonfunctional p53 protein production and cells with damaged DNA replicate in CSCC.4

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