Abstract： IntroductionAdult-onset Still's disease (AOSD) is a systemic infl ammatory disease with unknown etiology.It is classically characterized by a high spiking fever,evanescent rash,liver dysfunction,leukocytosis with neutrophilia,generalized lymphadenopathy,and splenomegaly.The typical skin rash of AOSD is evanescent,appearing and disappearing along with the rise and fall of the fever.However,recent reports have highlighted atypical rashes associated with AOSD,such as persistent pruritic plaques and papules.We herein report a case of AOSD with persistent pruritic papules on the chest in a 47-year-old woman,who was suspected of septicemia and lymphoma for more than 3 weeks before diagnosis confirmed.