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Relationships between PPARγ, TGF-β/Smad signaling pathway and psoriasis

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 2

DOI:: 10.3760/cma.j.issn.2096-5540.2018.02.007

Key Word:: No keyword available

Abstract： Introduction Psoriasis characterized by red scaly skin lesions clinically is a chronic inflammatory skin disease,and there are 0.53％-11.43％ of the adults around the world suffered[1].The pathophysiological changes of psoriasis are characterized by proliferation accelerated in epidermal basal keratinocytes and infiltration of inflammatory cells from epidermis and dermis.Many studies have shown that the occurrence and development of psoriasis is closely related to genes,cell signaling pathways and proliferation.The relationships between peroxisome proliferator-activated receptor-γ(PPARγ) and TGF-β/Smad signaling pathway and psoriasis has been mostly studied in recent years[2].

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