Abstract： Epigenetics is a kind of molecular phenomenon that refers to phenotypic changes inherited from one generation to the next without obvious alterations in DNA structures, including DNA methylation, histone modifications, chromatin remodeling, RNA interference, and so on. Of these issues,DNA methylation is the most widely researched with the most rapid progress. Melanoma, derived from the deric neural crest, shows the highest malignancy and lethality in all skin neoplasms. Recently, more and more researches have found that epigenetic changes have great importance for the occurrence and development of melanoma. This review summarizes progress in the association of melanoma development with epigenetic DNA methylation, histone modification and non?encoding sequences, which may be helpful to the diagnosis and prognosis of melanoma.