You Position: Home > Paper
Notch signaling in the pathogenesis of melanoma
( views:147, downloads:79 )
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2017.02.016
- Key Word:
- 黑色素瘤;受体,Notch1;Notch,信号通路;Dll 4配体;Dll 1配体;Melanoma;Receptor,Notch1;Notch,signaling pathway;Dll 4 ligands;Dll 1 ligands
Abstract： Melanoma,one of the malignant tumors in dermatology,has high invasive and metastatic capability,mortality,and poor prognosis.Currently,its occurrence is considered to be related to several abnormal signaling pathways,but the definite pathogenesis remains unclear.Notch receptors and their ligands are involved in the occurrence and metastasis of melanoma by regulating tumor angiogenesis and changing the adhesiveness of tumor cells,and affect the fate of melanoma by interacting with cells in other signaling pathways related to tumorigenesis.
- [1]Arndt F, Siekmann,Markus, Affolter,Heinz-Georg, Belting.The tip cell concept 10 years after: new players tune in for a common theme.[J].2013,319(9).
- [2]Giordano TJ,Polverini PJ,Li S,etc.Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling.[J].2005,8(1).
- [3]Postovit LM,Strizzi L,Hendrix MJ,etc.Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype.[J].2010,70(24).
- [4]Koch U.,Radtke F..Notch and cancer: a double-edged sword[J].2007,64(21).
- [5]Murtas, Daniela,Piras, Franca,Minerba, Luigi,etc.Activated Notch1 expression is associated with angiogenesis in cutaneous melanoma[J].2015,15(3).
- [6]Yu,S.,Ma,D.,Liu,N.,etc.Cross-talk between leukemic and endothelial cells promotes angiogenesis by VEGF activation of the Notch/Dll4 pathway[J].2013,34(3).
- [7]J P, Zhang,N, Li,W Z, Bai,etc.Notch ligand Delta-like 1 promotes the metastasis of melanoma by enhancing tumor adhesion.[J].2014,47(4).
- [8]Tarantini F,Leoncini G,Cirino G,etc.Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma.[J].2006,19(2).
- [9]Knyazev P,Wild PJ,Reschke M,etc.HER3 is a determinant for poor prognosis in melanoma.[J].2008,14(16).
- [10]Wang CM,Wei YN,Zhang JP,etc.Overexpression of Notch ligand Dll1 in B16 melanoma cells leads to reduced tumor growth due to attenuated vascularization.[J].2011,309(2).
- [11]Vartanian,A.,Dombrovsky,V.,Stepanova,E.,etc.The involvement of Notch signaling in melanoma vasculogenic mimicry[J].2013,13(3).
- [12]Howard, J.D.,Panova, I.P.,Levchenko, A.,etc.Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration[J].2013,26(5).
- [13]Zhang, K.,Wong, P.,Duan, J.,etc.An ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival[J].2013,26(3).
- [14]Benedito Rui,Rocha Susana F.,Woeste Marina,etc.Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling[J].2012,484(7392).
- [15]Ladstein,R.G.,Bachmann,I.M.,Straume,O.,etc.Nestin expression is associated with aggressive cutaneous melanoma of the nodular type[J].2014,27(3).
- [16]Garry HK Chang,Angelina J Lay,Ka Ka Ting,etc.ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions[J].2014,5(3).
- [17]Tilman Borggrefe,Matthias Lauth,An Zwijsen,etc.The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways[J].2016,1863(2).
- [18]Bridges E,Oon CE,Harris A.Notch regulation of tumor angiogenesis.[J].2011,7(4).
- [19]N.B. Iannucci,G.V. Ripoll,D.F. Alonso,etc.Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin[J].2011,12(11).
- [20]Barbara Bedogni.Notch signaling in melanoma: interacting pathways and stromal influences that enhance Notch targeting[J].2014,27(2).