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Relationship between acne and insulin resistance

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Author:: No author available

Journal Title:: 国际皮肤性病学杂志

Issue:: 1

DOI:: 10.3760/cma.j.issn.1673-4173.2017.01.010

Key Word:: 寻常痤疮;胰岛素样生长因子Ⅰ;吸烟;饮食习惯;胰岛素抵抗;Acne vulgaris;Insulin-like growth factor I;Smoking;Food habits;Insulin resistance

Abstract： Acne is a chronic inflammatory disease of the pilosebaceous unit with predilection for adolescents. Hormones are the most important endogenous factor for the occurrence of acne. Recently, it has been found that besides androgen, insulin resistance and abnormal levels of insulin and insulin?like growth factor?1(IGF?1)induced by insulin resistance were closely associated with acne. Concretely speaking, insulin and IGF?1 may participate in the occurrence of acne by indirectly stimulating androgen secretion and directly inducing keratinocyte proliferation, sebaceous lipogenesis and inflammatory responses. In addition, the fact that acne is an important clinical characteristic of some systemic diseases or syndromes, such as polycystic ovary syndrome(PCOS)and hyperandrogenism?insulin resistance?acanthosis nigricans (HAIR?AN)syndrome, and associations of acne with diet, smoking and tumors, all provide evidence for the potential role of insulin resistance in the occurrence of acne.

Reference

[1]肖学敏,张晓峰,李诚让,等.痤疮相关综合征的研究进展[J].2013,39(6).
[2]Miller, Lben Marie,McAndrew, Rachel J.,Hamzavi, Iltefat.Prevalence, Risk Factors, and Comorbidities of Hidradenitis Suppurativa[J].2016,34(1).
[3]S. Vora,A. Ovhal,H. Jerajani,etc.Correlation of facial sebum to serum insulin‐like growth factor‐1 in patients with acne[J].2008,159(4).
[4]Rami, Mortada,Tracy, Williams.Metabolic Syndrome: Polycystic Ovary Syndrome.[J].2015,435.
[5]Melnik BC,Schmitz G.Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris.[J].2009,18(10).
[6]Maddalena, Napolitano,Matteo, Megna,Giuseppe, Monfrecola.Insulin resistance and skin diseases.[J].2015,2015.
[7]Siobhan, Sutcliffe,Edward, Giovannucci,William B, Isaacs,etc.Acne and risk of prostate cancer.[J].2007,121(12).
[8]Pratt-Phillips, Shannon E.,Geor, Ray J.,McCutcheon, L. Jill.Comparison among the euglycemic-hyperinsulinemic clamp, insulin-modified frequently sampled intravenous glucose tolerance test, and oral glucose tolerance test for assessment of insulin sensitivity in healthy Standardbreds[J].2015,76(1).
[9]Zouboulis,C.C..Acne as a chronic systemic disease[J].2014,32(3).
[10]Errol, Prens,Inge, Deckers.Pathophysiology of hidradenitis suppurativa: An update.[J].2015,73(5 Suppl 1).
[11]Housman, Elizabeth,Reynolds, Rachel V..Polycystic ovary syndrome: A review for dermatologists Part I. Diagnosis and manifestations[J].2014,71(5).
[12]Melnik,B.C.,Zouboulis,C.C..Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne[J].2013,22(5).
[13]MELNIK, Bodo C.,JOHN, Swen Malte,PLEWIG, Gerd.Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance.[J].2013,93(6).
[14]Kumari,R.,Thappa,D..Role of insulin resistance and diet in acne[J].2013,79(3).
[15]Engels, Charla C.,de Glas, Nienke A.,Sajet, Anita,etc.The influence of insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis[J].2016,10(4).
[16]Del Prete Michela,Mauriello Maria Chiara,Faggiano Antongiulio,etc.Insulin resistance and acne: a new risk factor for men?[J].2012,42(3).
[17]Balta, Ilknur,Ekiz, Ozlem,Ozuguz, Pinar,etc.Insulin resistance in patients with post-adolescent acne[J].2015,54(6).
[18]Bodo C, Melnik.Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.[J].2015,8.
[19]Fabbrocini, G.,Izzo, R.,Faggiano, A.,etc.Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments[J].2016,41(1).
[20]Nazan, Emiro?lu,Fatma Pelin, Cengiz,Funda, Kemeriz.Insulin resistance in severe acne vulgaris.[J].2015,32(4).
[21]Braue A,Makelainen H,Smith RN,etc.A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial.[J].2007,86(1).
[22]Maluki AH.The frequency of polycystic ovary syndrome in females with resistant acne vulgaris.[J].2010,9(2).
[23]Chen W,Obermayer Pietsch B,Hong JB,etc.Acne-associated syndromes: models for better understanding of acne pathogenesis.[J].2011,25(6).
[24]Melnik, Bodo C..Western diet-induced imbalances of FoxO1 and mTORC1 signalling promote the sebofollicular inflammasomopathy acne vulgaris[J].2016,25(2).
[25]Varigos G.,Makelainen H.,Mann N.,etc.A pilot study to determine the short-term effects of a low glycemic load diet on hormonal markers of acne: a nonrandomized, parallel, controlled feeding trial.[J].2008,52(6).