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Skin aging and microRNAs

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Journal Title:
International Journal of Dermatology and Venereology
Key Word:
皮肤衰老;微RNAs;真皮;角蛋白细胞;紫外线;郎格尔汉斯细胞;Skin aging;MicroRNAs;Dermis;Keratinocytes;Ultraviolet rays;Langerhans cells

Abstract´╝Ü Skin aging,a manifestation of body senescence,is caused by changes of cellular structures and functions,as well as extracellular matrix (ECM) components in the epidermis and dermis.MicroRNAs (miRNAs),a kind of small non-coding endogenous RNA molecule,have been demonstrated to be related to senescence of the epidermis and dermis as well as ultraviolet (UV)-induced skin aging.In the dermis,miRNAs can affect the senescence of fibroblasts by targeting ECM components and cellular adhesion molecules,or by regulating cell cycle,telomerase activity,intracellular signaling pathways,oxidative stress,and so on.In the epidermis,miRNAs play a role in the senescence of keratinocytes through chromatin remodeling and the P63 pathway,and affect the senescence of Langerhans cells by targeting the transforming growth factor-β-dependent/independent pathway.In UV-induced skin aging,miRNAs participate in the process of skin aging via histone methylation,cell cycle regulators,transcriptional activitors,and so on.In addition,some miRNAs such as miR-125b participate in skin aging likely through epidermal stem cells.

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