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Adiponectin and its correlation with psoriasis

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Author:
No author available
Journal Title:
International Journal of Dermatology and Venereology
Issue:
4
DOI:
10.3760/cma.j.issn.1673-4173.2016.04.007
Key Word:
银屑病;脂联素;受体,脂联素;脂肪因子类;信号传导;Psoriasis;Adiponectin;Receptors,adiponectin;Adipokines;Signal transduction

Abstract: Adipose tissue not only can store excess energy,but also serves as an active endocrine organ secreting a variety of bioactive substances,such as leptin and adiponectin.These substances are called adipokines,and are important mediators of the interaction between host nutritional status and the neuroendocrine-immune system.Adipocytes and macrophages both participate in the release of proinflammatory cytokines,such as tumor necrosis factor (TNF),interleukin-6 (IL-6),IL-8,monocyte chemotactic protein-1 (MCP-1) and adipokines (including adiponectin,leptin,resistin,and so on).Adiponectin is not only closely associated with obesity and insulin resistance,but also has anti-inflammatory and vascular protective effects.Some cytokines such as TNF-α and IL-6 can inhibit the expression of adiponectin in vitro,while adiponectin can suppress the secretion of TNF-α,IL-6,IL-17,IL-22 and interferon γby keratinocytes and T lymphocytes.The level of adiponectin is negatively correlated with the severity of psoriasis as well as levels of TNF-α and IL-6.

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