Abstract: Adipose tissue not only can store excess energy,but also serves as an active endocrine organ secreting a variety of bioactive substances,such as leptin and adiponectin.These substances are called adipokines,and are important mediators of the interaction between host nutritional status and the neuroendocrine-immune system.Adipocytes and macrophages both participate in the release of proinflammatory cytokines,such as tumor necrosis factor (TNF),interleukin-6 (IL-6),IL-8,monocyte chemotactic protein-1 (MCP-1) and adipokines (including adiponectin,leptin,resistin,and so on).Adiponectin is not only closely associated with obesity and insulin resistance,but also has anti-inflammatory and vascular protective effects.Some cytokines such as TNF-α and IL-6 can inhibit the expression of adiponectin in vitro,while adiponectin can suppress the secretion of TNF-α,IL-6,IL-17,IL-22 and interferon γby keratinocytes and T lymphocytes.The level of adiponectin is negatively correlated with the severity of psoriasis as well as levels of TNF-α and IL-6.