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Roles of interleukin-27 in the pathogenesis of psoriasis
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- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4173.2016.03.012
- Key Word:
- 银屑病;白细胞介素27;受体,白细胞介素;信号传导;免疫;Psoriasis;Interleukin-27;Receptors,interleukin;Signal transduction;Immunity
Abstract： Interleukin-27 (IL-27),a cytokine belonging to the IL-12 family,plays an important role in the regulation of different types of immunocytes.It is a heterodimeric cytokine composed of two subunits,namely the p28 and Epstein-Barr virus (EBV)-induced gene 3 (EBi3),and is produced by activated antigen-presenting cells.Its receptor is composed of WSX-1 and gp130.IL-27 can bind to its receptor,then activate the signal transducer and activator of transcription (STAT) signaling pathway.With further insights into the role of IL-27 in the pathogenesis of psoriasis,IL-27 and its receptor may become new targets for the treatment of psoriasis.
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