Genetic susceptibility to Mycobacterium infections
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2016.01.003
- Key Word:
- 分枝杆菌感染;基因;结核分枝杆菌;麻风分枝杆菌;非结核分枝杆菌;Mycobacterium infections;Genes;Mycobacterium tuberculosis;Mycobacterium leprae;Nontuberculous mycobacteria
Abstract： Human pathogenic mycobacteria, including Mycobacterium tuberculosis, Mycobacterium leprae and non-tuberculosis mycobacteria, greatly threaten human health.Mycobacterium infections are closely related to the host genetic background.Studies have indicated that host genes play important roles in Mycobacterium infections.Recently, a variety of genes have been identified to be associated with the susceptibility to Mycobacterium infections by genome-wide association studies, large-scale population-based case/control studies on candidate genes, family-based linkage studies and investigations of rare individuals with exceptional mycobacterial susceptibility, including interleukin (IL)-12B, IL-12RB1, IFNGR1, IFNGR2, TLRs, NOD2, MRC1, IRGM, NRAMP1, VDR, LTA4H, etc.Researches on these predisposing genes may contribute to the elucidation of immunologic mechanisms of Mycobacterium infections, and provide a theoretical basis for screening for populations at high risks of leprosy and tuberculosis and for prevention from Mycobacterium infections.
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