Abstract: As a kind of monochromatic ultraviolet B,308-nm monochromatic excimer light (MEL) is one of the first choice treatments for vitiligo.There is no significant difference in the therapeutic effect on vitiligo between 308-nm MEL and 308-nm excimer laser.Recent studies have shown that 308-nm MEL can also serve as the treatment of choice for some other chronic skin diseases,such as psoriasis,palmoplantaris pustulosis and alopecia areata.Furthermore,there have been case reports on the use of 308-nm MEL for the treatment of achromic naevus,mycosis fungoides,CD30+ lymphomatoid papulosis,lichen sclerosus,prurigo nodularis,localized scleroderma,granuloma annulare and plasma cell cheilitis.Compared with conventional phototherapy,308-nm MEL has the advantages of less cumulative radiation dose and lower risks of skin cancers.The main adverse reaction to 308-nm MEL is transient erythema.The therapeutic mechanism of 308-nm MEL is still unclear.