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Anti-inflammatory and immunoregulatory properties of tetracyclines and their clinical application in dermatology

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 5

DOI:: 10.3760/cma.j.issn.1673-4173.2015.05.008

Key Word:: 四环素类;免疫调节;炎症;红斑痤疮;寻常痤疮;Tetracyclines;Immunomodulation;Inflammation;Rosacea;Acne vulgaris

Abstract： Tetracyclines not only have strong antibacterial effects,but also have definite anti-inflammatory and immunoregulatory effects.The action mechanisms of tetracyclines mainly include inhibition of matrix metalloproteinases,clearance of reactive oxygen species and nitric oxide,suppression of granuloma formation and angiogenesis,inhibition of inflammatory cytokines and apoptosis,etc.Tetracyclines have become a choice for the medical treatment of acne rosacea and acne.Also,they have been attempted in the treatment of other non-infectious dermatoses such as bullous skin diseases and neutrophilic dermatosis.It is of great significance to learn advances in studies of tetracyclines and to fully and properly utilize their non-antibacterial properties in the treatment of various inflammatory and autoimmune diseases in dermatology.

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