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Alpha-melanocyte stimulating hormone analogues and their inducers for the treatment of vitiligo

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Author:
No author available
Journal Title:
International Journal of Dermatology and Venereology
Issue:
4
DOI:
10.3760/cma.j.issn.1673-4173.2015.04.007
Key Word:
α促黑素;白癜风;性类固醇甲状腺激素;小眼畸形相关转录因子;α-MSH衍生物;alpha-MSH;Vitiligo;Sex steroid thyroid hormone;Microphthalmia-associated transcription factor;alpha-MSH derivatives

Abstract: Alpha-melanocyte stimulating hormone (α-MSH),the strongest endogenous immunomodulatory small-molecule neuroendocrine peptide among melanocyte stimulating hormones,is mainly produced in the pituitary gland.α-MSH can promote melanocytes to proliferate and produce melanosomes,regulate the differentiation of melanocytes through the microphthalmia-associated transcription factor,and finally cause skin pigmentation.Many studies have shown that α-MSH levels are decreased in the epidermis and sera in patients with vitiligo.The α-MSH analogue afamelanotide,which can induce the expression of α-MSH by melanocytes,and the sex steroid thyroid hormone metharmon-F,both can be used to treat vitiligo through action on melanocytes,and have been lately recommended for the treatment of vitiligo at clinics.

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