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Relationship between dendritic cell subsets and psoriasis
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- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2015.01.013
- Key Word:
- 银屑病;树突细胞;抗原,CD11c;Psoriasis;Dendritic cells;Antigens,CD11c
Abstract： Psoriasis is a chronic inflammatory and immunologic disease of unknown etiology.It has been found that increased number of dendritic cells (DCs) and effector T-lymphocytes infiltrate skin lesions of psoriasis,indicating that DCs are involved in the inflammatory response in psoriasis.In normal skin,there are mainly three kinds of DCs:epidermal Langerhans cells,dermal myeloid DCs and plasmacytoid DCs.In skin lesions of psoriasis,the three kinds of DCs interact with T cells,keratinocytes and neutrophilic granulocytes,which can induce and aggravate inflammatory responses.In addition,type Ⅰ interferon secreted by plasmacytoid DCs in a Toll-like receptor-dependent manner can enhance the activation of myeloid DCs and release of inflammatory mediators.
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