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Belimumab: targeted therapy for systemic lupus erythematosus

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Journal Title:
International Journal of Dermatology and Venereology
Key Word:
红斑狼疮,系统性;贝利木单抗;分子靶向治疗;Lupus erythematosus,systemic;Belimumab;Molecular targeted therapy

Abstract´╝Ü Systemic lupus erythematosus (SLE) is a systemic autoimmune disease,whose exact pathogenesis is not fully clear as yet.The abnormal activation of B cells plays an important role in the development of SLE,and B cell-activating factor (BAFF) is critical for the abnormal activation of B cells.Belimumab is a human monoclonal antibody which can selectively recognize and block soluble BAFF.The efficacy and safety of belimumab have been confirmed for the treatment of SLE in randomized,double-blind,large-scale clinical trials.As a biological agent with high efficacy,few side effects and high tolerability,belimumab is a promising drug for SLE.

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