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Chemokines in the pathogenesis of psoriasis

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Author:
No author available
Journal Title:
International Journal of Dermatology and Venereology
Issue:
3
DOI:
10.3760/cma.j.issn.1673-4173.2013.03.014
Key Word:
银屑病;趋化因子类;治疗;Psoriasis;Chemotactic factors;Therapy

Abstract: Psoriasis is a common,inflammatory and proliferative disease of the skin.The creation and maintenance of psoriatic lesions require a multicellular conspiracy by which prepsoriatic skin becomes infiltrated by a variety of immunocytes triggering changes in the behavior of epidermal keratinocytes and endothelial cells.Chemokines,as a group of cytokines capable of directing cells trafficking,can be divided into 4 subclasses.They induce T cells and other cells to migrate to and reside in the skin during physiologicalresponses in inflamed or infected skin,and play important roles in the pathophysiology of psoriasis.

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