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A case of dermatofibrosarcoma protuberans

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Journal Title:
International Journal of Dermatology and Venereology
Key Word:
皮肤纤维肉瘤;病例报告;Dermatofibrosarcoma;Case reports

Abstract´╝Ü A 52-year-old female patient presented with erythematous nodules and plaques for 10 years in the left lower abdomen,which had been aggravated in the past half year.Physical examination revealed several soy bean-to finger-sized,smooth,soft,rubber like,erythematous papules and nodules,and a few irregularly sized,moderately indurated subcutaneous nodules and masses with a yellowish red smooth surface in the left lower abdomen,giving a rough appearance.Skin biopsy revealed a large number of spindle tumor cells arranged in a storiform pattern throughout the full-thickness dermis and subcutaneous tissue with the involvement of skin appendages.A few mitotic figures were observed in some tumor cells.Immunohisto-chemistry of the tumor cells showed positive staining for CD34,vimentin and BCL-2,but negative staining for neuron specific enolase (NSE),synaptophysin (Syn),soluble protein 100 (S-100),smooth muscle actin (SMA) and XⅢa.A diagnosis of dermatofibrosarcoma protuberans was made according to the clinical,histopathologic and immunohistochemical manifestations.The patient received extended radical excision followed by skin grafting and achieved a satisfactory outcome.No recurrence was observed during a 5-month follow up.

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