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遗传性出血性毛细血管扩张症一家系六例
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- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1673-4173.2012.03.022
- Key Word:
- No keyword available
Abstract： 患者女,63岁.因面部、舌部红色皮疹伴鼻出血30余年,牙龈反复出血半年余,于2010年5月来本院就诊.患者于30137岁时发现面部、舌部有多个红色丘疹,无痒痛感,未予治疗.近半年来牙龈处发现粟粒大小的红色增生物,经常破溃出血.曾就诊于口腔科,诊断为牙龈炎.给予清洁口腔、抗炎治疗,无明显疗效.否认肝炎、结核、血液病等病史.其家族中多人有反复鼻出血病史.体检:全身皮肤黏膜无黄染,浅表淋巴结未触及明显肿大,各系统检查未见异常.皮肤科检查:面部、舌体、牙龈及手指掌侧见多个鲜红色或紫红色丘疹,针尖至绿豆大小,压之褪色(图1,2).实验室检查:血、尿、粪常规均正常.活化部分凝血时间测定32.4 s,凝血酶原时间12.1 s.甲胎蛋白及血浆蛋白电泳均正常.抗核抗体、可提取核抗原抗体及类风湿因子均阴性.心电图、胸部X线片均正常.
- [1]Chng SM,Ozanne A,Rodesch G,etc.Hereditary hemorrhagic telangiectasia in children: endovascular treatment of neurovascular malformations: results in 31 patients.[J].2005,47(12).
- [2]Yamada Y,Hori Y,Kiyosue H,etc.Intrahepatic porto-hepatic venous shunts in Rendu-Osler-Weber disease: imaging demonstration.[J].2004,14(4).
- [3]Letarte M,Shovlin CL.Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms.[J].1999,54(8).