Abstract: Cytokines play an important immunomodulatory effect in the development of deep fungal infection.Recently,immunomodulation therapy has gradually become a hot spot in the treatment of deep fungal infection.Cell factors are mainly classified into 2 categories:pro-inflammatory cytokines and anti-inflammatory cytokines.Pro-inflammatory cytokines mainly include tumor necrosis factor (TNF)-α,colony stimulating factor (CSF),interferon-γ(IFN-γ),interleukin-12 (IL-12),etc,and anti-inflammatory cytokines include IL-4,IL-10,and so on.The essential roles of pro-inflammatory cytokines in immune response and immune regulation make them have great potential for the treatment of deep fungal infection.This paper focuses on the roles of cytokines in deep fungal infection.