Skin-derived antimicrobial peptides
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2012.02.015
- Key Word:
- 表皮;防御素类;Cathelicidins;皮肤屏障;Epidermis;Defensins;Cathelicidins;Skin barrier
Abstract： Antimicrobial peptides refer to all of the peptides with antimicrobial activity expressed in various types of organisms.Skin-derived antimicrobial peptides play an important role in the protection of skin against infection by frequently contacting microbes in the environment.They mainly consist of defensins and cathelicidin LL-37.Since skin-derived antimicrobial peptides possess a series of advantages which are lacked by common antibiotics,their biological activity and correlation with skin barrier have become a hot spot in present studies.Further researches into skin-derived antimicrobial peptides will provide new hopes for thedefense against diseases,delay of aging,disclosure of pathogenesis of and development of treatment for somedermatoses.
- [1]Andra J,Lamata M,Martinez De Tejada G,etc.Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide.[J].2004,68(7).
- [2]Schroder JM,Wittersheim M,Mrowietz U,etc.Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.[J].2010,130(5).
- [3]Ong PY,Boguniewicz M,Ohtake T,etc.Endogenous antimicrobial peptides and skin infections in atopic dermatitis.[J].2002,347(15).
- [4]Gulsun, Erdag,Jeffrey R, Morgan.Interleukin-1alpha and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts.[J].2002,235(1).
- [5]Sorensen O,Kratz G,Heilborn JD,etc.The Cathelicidin Anti-Microbial Peptide LL-37 is Involved in Re-Epithelialization of Human Skin Wounds and is Lacking in Chronic Ulcer Epithelium.[J].2003,120(3).
- [6]Otte JM,Brand S,Zdebik AE.Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity.[J].2009,156(1).
- [7]Gallo RL,Hata TR.Antimicrobial peptides, skin infections, and atopic dermatitis.[J].2008,27(2).
- [8]Meyer Hoffert U,Schwarz T,Schroder JM,etc.Increased expression of human beta-defensin 3 in mollusca contagiosum.[J].2010,35(2).
- [9]Mi H,Lin X,Zhang G,etc.A peptide fragment derived from the T-cell antigen receptor protein alpha-chain adopts beta-sheet structure and shows potent antimicrobial activity.[J].2009,30(4).
- [10]Duarte B,Carretero M,Holguin A,etc.In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37.[J].2008,128(1).
- [11]Yamasaki K,Di-Nardo A,Bardan A,etc.Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea.[J].2007,13(8).
- [12]Sathiah Thennarasu,Gianluigi Veglia,Fernando Porcelli,etc.Structures of the Dimeric and Monomeric Variants of Magainin Antimicrobial Peptides (MSI-78 and MSI-594) in Micelles and Bilayers, Determined by NMR Spectroscopy[J].2006,45(18).
- [13]Altmeyer P,Kobus A,Skrygan M,etc.Expression of antimicrobial peptides and proteins in etanercept-treated psoriasis patients.[J].2011,167(2).
- [14]Hancock RE,Hale JD.Alternative mechanisms of action of cationic antimicrobial peptides on bacteria.[J].2007,5(6).
- [15]Niyonsaba F,Ushio H,Nakano N,etc.Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.[J].2007,127(3).
- [16]Kajiwara N,Nagaoka I,Niyonsaba F,etc.Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.[J].2010,184(7).
- [17]Okumura K,Nagaoka I,Niyonsaba F,etc.The Human {beta}-Defensins (-1, -2, -3, -4) and Cathelicidin LL-37 Induce IL-18 Secretion through p38 and ERK MAPK Activation in Primary Human Keratinocytes.[J].2005,175(3).