Nrf2-Keap1 system protects the skin from ultraviolet damage: an update
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.05.015
- Key Word:
- 紫外线;损伤;活性氧;Ultraviolet rays;Injuries;Reactive oxygen species
Abstract： Ultraviolet irradiation is an important environmental factor causing skin photodamage, which is associated with the induction of reactive oxygen species (ROS) generation. Nuclear factor E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant responses, and kelch-like ECH-associated protein 1 (Keap1) is its specific receptor. After activated by ultraviolet-induced oxidative stress or other factors, Nrf2 detaches from Keap1 and enters into the cell nucleus followed by the triggering of expression of antioxidase genes and antioxidant response element-regulated phase 2 enzyme genes, which in turn protect the skin from ultraviolet damage. Many agonists of Nrf2 have a potential protective effect against ultraviolet-induced injury to skin.
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