Effects of topical glucocorticosteroids on skin barrier function
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.05.009
- Key Word:
- 糖皮质激素类;投药,局部;屏障;皮肤;Glucocorticoids;Administration,topical;Barrier;Skin
Abstract： Short-term use of topical glucocorticosteroids will dramatically reduce the recovery time of skin barrier, and long-term application may alter the structure and function of skin barrier. The mechanisms underlying glucocorticosteroid-induced destruction of skin barrier are multitudinous, including the inhibition of keratinocyte proliferation as well as the influence on the differentiation of keratin and filaggrin and on the formation of corneodesmosomes and intercellular lipid matrices. Therefore, skin barrier-protecting products should be used in the treatment of glucocorticosteroid addictive dermatitis and combined with glucocorticosteroid during the treatment of skin diseases.
- [1]林宗贤,项蕾红.皮肤屏障功能研究进展[J].2008,34(6).
- [2]马敬,艾东方,杨秀芳.银屑病的治疗对相关角蛋白的影响[J].2010,(1).
- [3]H.‐M. SHEU,J.Y.‐Y. LEE,C.‐Y. CHAI,etc.Depletion of stratum corneum intercellular lipid lamellae and barrier function abnormalities after long‐term topical corticosteroids[J].1997,136(6).
- [4]Schoepe S,Schacke H,May E,etc.Glucocorticoid therapy-induced skin atrophy.[J].2006,15(6).
- [5]Y, Sandjeu,M, Haftek.Desmosealin and other components of the epidermal extracellular matrix.[J].2009,60 Suppl 4.
- [6]Demerjian M,Choi EH,Man MQ,etc.Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.[J].2009,18(7).
- [7]L, Kolbe,A M, Kligman,V, Schreiner,etc.Corticosteroid-induced atrophy and barrier impairment measured by non-invasive methods in human skin.[J].2001,7(2).
- [8]Elias PM,Man MQ,Feingold KR,etc.Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.[J].2003,120(3).
- [9]Jho SH,Radoja N,Im MJ,etc.Negative response elements in keratin genes mediate transcriptional repression and the cross-talk among nuclear receptors.[J].2001,276(49).
- [10]VanDerVelden,H.M.J.,Pasch,M.C.,VanErp,P.E.J.,etc.Treatment of plaque psoriasis with the two-compound product calcipotriol/betamethasone dipropionate versus both monotherapies: An immunohistochemical study[J].2010,21(1/2).
- [11]Agner T,Jemec GB,Jungersted JM,etc.Lipids and skin barrier function--a clinical perspective.[J].2008,58(5).
- [12]Donet E,Bosch P,Sanchis A,etc.Transrepression function of the glucocorticoid receptor regulates eyelid development and keratinocyte proliferation but is not sufficient to prevent skin chronic inflammation.[J].2008,22(4).