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Human β-defensin-2 and skin diseases
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1673-4173.2010.06.016
- Key Word:
- 皮肤疾病;β防御素;研究;Skin diseases;β-defensins;Research
Abstract： Human β-defensin-2 (hBD-2) is an endogenous antimicrobial peptide recently found in the skin with broad-spectrum antimicrobial activity and unique mechanism of function. Recent studies have confirmed that the expression of hBD-2 is upregulated in the lesions of some dermatoses, such as psoriasis,acne vulgaris, verruca, dermatophytosis and basal cell carcinoma, etc. The susceptibility to bacterial and viral infections may be associated with the decreased or absent expression of hBD-2. Further researches into HBD-2will provide a new direction for the prevention and treatment of skin diseases.
- [1]Nadine, Steubesand,Karlheinz, Kiehne,Gabriele, Brunke,etc.The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.[J].2009,10.
- [2]Brockmeyer NH,Altmeyer P,Tomi NS,etc.Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin.[J].2008,147(1).
- [3]Byeong-Churl Jang,Ki-Jo Lim,Min-Ho Suh,etc.Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells.[J].2007,51(1).
- [4]Tajamul, Hussain,Najmunnisa, Nasreen,Yimu, Lai,etc.Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of beta-defensin-2 by staphylococcal peptidoglycan.[J].2008,295(3).
- [5]S. Rieg,C. Garbe,B. Sauer,etc.Dermcidin is constitutively produced by eccrine sweat glands and is not induced in epidermal cells under inflammatory skin conditions[J].2004,151(3).
- [6]Darmstadt GL,Dinulos JG,Fredericks LP,etc.Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense.[J].2003,10(1).
- [7]Schroder JM,Proksch E,Neumann C,etc.Barrier function, epidermal differentiation, and human beta-defensin 2 expression in tinea corporis.[J].2007,127(7).
- [8]Nakatsuji T,Kao MC,Zhang L,etc.Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression.[J].2010,130(4).
- [9]Wehkamp K,Schwichtenberg L,Schroder JM,etc.Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1.[J].2006,126(1).
- [10]Beom Joon,Kim.The effect of calcipotriol on the expression of human beta defensin-2 and LL-37 in cultured human keratinocytes.[J].2009,2009.
- [11]T, Gambichler,M, Skrygan,J, Huyn,etc.Pattern of mRNA expression of beta-defensins in basal cell carcinoma.[J].2006,6.
- [12]Masaaki Kawai,Masashi Yamazaki,Ryoji Tsuboi,etc.Human β‐defensin‐2, an antimicrobial peptide, is elevated in scales collected from tinea pedis patients[J].2006,45(11).
- [13]Cho SY,Lee KS,Cho JW.Roles of SEA-expressing Staphylococcus aureus, isolated from an atopic dermatitis patient, on expressions of human beta-defensin-2 and inflammatory cytokines in HaCaT cells.[J].2009,23(3).
- [14]Hollox, Edward J.,Huffmeier, Ulrike,Zeeuwen, Patrick L. J. M.,etc.Psoriasis is associated with increased β-defensin genomic copy number.[J].2008,40(1).
- [15]Huang LC,Redfern RL,Narayanan S,etc.In vitro activity of human beta-defensin 2 against Pseudomonas aeruginosa in the presence of tear fluid.[J].2007,51(11).
- [16]Jenny Kim.Review of the Innate Immune Response in Acne vulgaris: Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses[J].2005,211(3).
- [17]Meyer-Hoffert U,Schroder JM,Glaser R,etc.Expression of human beta-defensin-2 and -3 in verrucae vulgares and condylomata acuminata.[J].2008,22(9).
- [18]Harder J.,Bartels J.,Christophers E,etc.A peptide antibiotic from human skin[J].1997,387(6636).