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Aquaporin 3 and skin

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-4173.2010.06.014

Key Word:: 水通道蛋白质3;皮肤疾病;关系;Aquaporin 3;Skin diseases;Relations

Abstract： Aquaporins (AQPs) are a group of membrane transport proteins involved in the transport ofwater across cell membranes. AQP3, the most abundant aquaporin subset in human skin, is permeable notonly to water but also to small solutes such as glycerol. It has been reported that AQP3-knockout mice havereduced stratum corneum water content, elasticity and impaired wound healing. AQP3 has been revealed to berelated to cell proliferation and migration, and involved in the initiation, progression and metastasis of tumors.In addition, AQP3 expression is associated with the pathogenesis of inflammatory cutaneous diseases such asatopic dermatitis and erythema toxicum neonatorum. AQP3 expression can be modulated by multiple factorssuch as retinoic acid and tumor necrosis factor α, and this modulation may provide a new clue for the therapyof related skin diseases.

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